化学与生物工程
化學與生物工程
화학여생물공정
CHEMISTRY & BIOENGINEERING
2014年
7期
44-46
,共3页
4-哌啶酮%二氮杂螺5,5十一烷%9-Boc-1-氧-4,9-二氮杂螺5,5十一烷
4-哌啶酮%二氮雜螺5,5十一烷%9-Boc-1-氧-4,9-二氮雜螺5,5十一烷
4-고정동%이담잡라5,5십일완%9-Boc-1-양-4,9-이담잡라5,5십일완
4-piperidone%diazaspiro[5,5]undecane%9-Boc-1-oxo-4,9-diazaspiro[5,5] undecane
以N-Boc-4-哌啶酮为原料，经亲核加成、氢化还原、氯乙酰化、环化及还原等反应合成目标产物9-Boc-1-氧-4，9-二氮杂螺[5，5]十一烷，并对其中影响收率的关键步骤进行优化，得到了反应条件温和、操作简便、收率高的合成路线，总收率达50％。
以N-Boc-4-哌啶酮為原料，經親覈加成、氫化還原、氯乙酰化、環化及還原等反應閤成目標產物9-Boc-1-氧-4，9-二氮雜螺[5，5]十一烷，併對其中影響收率的關鍵步驟進行優化，得到瞭反應條件溫和、操作簡便、收率高的閤成路線，總收率達50％。
이N-Boc-4-고정동위원료，경친핵가성、경화환원、록을선화、배화급환원등반응합성목표산물9-Boc-1-양-4，9-이담잡라[5，5]십일완，병대기중영향수솔적관건보취진행우화，득도료반응조건온화、조작간편、수솔고적합성로선，총수솔체50％。
The target compound 9-Boc-1-oxo-4,9-diazaspiro[5,5]undecane was synthesized from N-Boc-4-piperidone as raw material by the reaction of nucleophilic addition,hydrogenation,acetylation,cyclization and re-duction.By the optimization of key steps,a synthetic route with mild reaction conditions,simple operation and high yield was obtained.The total yield reached 50%.
