CAJ | 학술논문

目的：探讨药物性肝损伤患者的临床特点及发病因素。方法回顾性分析药物性肝损伤患者服药史、临床表现、基础疾病、治疗及转归等。结果200例患者中女139例，男61例，涉及药品169种，其中前3位是中药（48．5％）、抗感染药（11．2％）、抗肿瘤药（8．2％）。患者基础疾病主要为心血管病（14．5％）、感染性疾病（10．3％）、皮肤病（8．8％）、骨关节病（8．4％）、肿瘤（7．9％）等。200例患者治愈146例，好转53例，死亡1例。结论引起肝损伤的药物以中药为主，临床表现形式多样，但转归较好。
목적：탐토약물성간손상환자적림상특점급발병인소。방법회고성분석약물성간손상환자복약사、림상표현、기출질병、치료급전귀등。결과200례환자중녀139례，남61례，섭급약품169충，기중전3위시중약（48．5％）、항감염약（11．2％）、항종류약（8．2％）。환자기출질병주요위심혈관병（14．5％）、감염성질병（10．3％）、피부병（8．8％）、골관절병（8．4％）、종류（7．9％）등。200례환자치유146례，호전53례，사망1례。결론인기간손상적약물이중약위주，림상표현형식다양，단전귀교호。
Objective To investigate the characteristics and risk etiological factors of drug-induced liver injury(DILI) cases,and provide information for clinical prevention and treatment.Methods The clinical data of 200 patients (including 139 female and 71 male ) with DILI was retrospectively analyzed according to their history of medicine, clinical manifestations,underlying diseases,treatment and prognosis.Results These 200 cases involved 169 etiological drugs,of which the top 3 were traditional Chinese medicine,anti-infective drugs and anti-tumor drugs.The primary underlying diseases of these patients were cardiovascular disease,infectious diseases,skin diseases,osteoarthrosis,tumors and so on. Of those 200 patients,146 were cured,53 improved and 1 died.Conclusion DILI is dominated by traditional Chinese medicine,with various clinical manifestations and favorable prognosis.