CAJ | 학술논문

目的：分析非甾体抗炎药（NSAIDs）引起小肠损伤的胶囊内镜下特点。方法：将小肠损伤患者74例根据1周前是否服用NSAIDs分为观察组与对照组，比较2组胶囊内镜下的病变部位和性质差异。结果：观察组无症状为71.4%，高于对照组25.6%，差异具有统计学意义(P＜0.05)，对照组消化道出血、腹痛、腹泻均高于观察组，差异具有统计学意义(P＜0.05)；观察组胶囊内镜下检查出溃疡率为22.9%，高于对照组的15.4%，且具有统计学意义(P＜0.05)，对照组胶囊内镜下出血率、孤立溃疡率较观察组高，具有统计学意义(P＜0.05)，肠黏膜糜烂2组比较未见明显差异(P＞0.05)。结论：胶囊内镜下非甾体抗炎药的损伤主要为黏膜糜烂，其溃疡表现为直径＜1 cm溃疡，多发，为表浅性溃疡，较未服用药者溃疡表现有较大差别，故胶囊内镜的使用有利于鉴别及相关治疗，且检查前服用胃肠汤剂可有效减少胶囊滞留的发生，并有益于病变的检出。
목적：분석비치체항염약（NSAIDs）인기소장손상적효낭내경하특점。방법：장소장손상환자74례근거1주전시부복용NSAIDs분위관찰조여대조조，비교2조효낭내경하적병변부위화성질차이。결과：관찰조무증상위71.4%，고우대조조25.6%，차이구유통계학의의(P＜0.05)，대조조소화도출혈、복통、복사균고우관찰조，차이구유통계학의의(P＜0.05)；관찰조효낭내경하검사출궤양솔위22.9%，고우대조조적15.4%，차구유통계학의의(P＜0.05)，대조조효낭내경하출혈솔、고립궤양솔교관찰조고，구유통계학의의(P＜0.05)，장점막미란2조비교미견명현차이(P＞0.05)。결론：효낭내경하비치체항염약적손상주요위점막미란，기궤양표현위직경＜1 cm궤양，다발，위표천성궤양，교미복용약자궤양표현유교대차별，고효낭내경적사용유리우감별급상관치료，차검사전복용위장탕제가유효감소효낭체류적발생，병유익우병변적검출。
Objective: To explore the features of non-steroid anti-inflammatory drugs (NSAIDs) induced small intestine injury under capsule endoscope. Methods: Seventy-four patients were allocated to the observation group and the control group in accordance with whether they take NSAIDs one week ago, the lesions and the property of both groups were compared under capsule endoscope. Results: Asymptomatic ratio of the observation group was 71.4%, higher than 25.6% of the control group, the difference showed statistical meaning (P<0.05); the control group was higher than the observation group in the ratio of hemorrhage of digestive tract, abdominal pain, diarrhea, the difference indicated statistical meaning (P<0.05); exam ulcer rate under capsule endoscope of the observation group was 22.9%, higher than 15.4% of the control group, the difference demonstrated statistical meaning (P<0.05); the control group was higher than the observation group in bleeding rate under capsule endoscope and solitary ulcer rate, the difference presented statistical meaning (P<0.05); there was no significant difference between both groups in intestinal mucosal erosion (P>0.05). Conclusion: The injury of NSAIDs under capsule endoscope is mainly mu-cosal erosion, the ulcer is less than 1cm, multiple and superficial one, ulcer expresses significant difference com-pared with the patients who didn't take NSAIDs, which is helpful to differentiate the ulcer and the related treatment. Taking decoction before examination could effectively reduce capsule retention, and it is helpful to detect the le-sions.