CAJ | 학술논문

目的：探讨防风感冒颗粒的解热和抗炎作用。方法：采用脂多糖(LPS)致兔发热模型和干酵母致大鼠发热模型，观察防风感冒颗粒的解热作用；采用二甲苯致小鼠耳廓肿胀模型和蛋清致大鼠足趾肿胀模型，检测炎症组织中PGE2的含量，观察防风感冒颗粒的抗炎作用。结果：与空白对照组比较，防风感冒颗粒能显著降低LPS致兔发热模型和干酵母致大鼠发热模型的体温(P＜0.05)，能抑制二甲苯致小鼠耳廓肿胀和蛋清致大鼠足趾肿胀的炎症反应(P＜0.05)，并能减少炎症组织中PGE2的含量(P＜0.05)。结论：防风感冒颗粒具有良好的解热和抗炎作用。
목적：탐토방풍감모과립적해열화항염작용。방법：채용지다당(LPS)치토발열모형화간효모치대서발열모형，관찰방풍감모과립적해열작용；채용이갑분치소서이곽종창모형화단청치대서족지종창모형，검측염증조직중PGE2적함량，관찰방풍감모과립적항염작용。결과：여공백대조조비교，방풍감모과립능현저강저LPS치토발열모형화간효모치대서발열모형적체온(P＜0.05)，능억제이갑분치소서이곽종창화단청치대서족지종창적염증반응(P＜0.05)，병능감소염증조직중PGE2적함량(P＜0.05)。결론：방풍감모과립구유량호적해열화항염작용。
Objective: To observe relieving fever and anti-inflammatory effects ofFangFengGanMaogranules. Methods: The rabbit model with fever was established with lipopolysaccharide (LPS) and rat model suffering from fever by dried yeast, relieving fever ofFangFengGanMaogranules was investigated; mice with ear swelling were caused by dimethylbenzene and rats with toe swelling by albumen, the contents of PGE2 were detected in the inflam-matory tissue to observe anti-inflammatory effects ofFangFengGanMaogranules. Results: Compared with blank control group, the granules could obviously decrease the temperature of rabbit model suffering from fever induced by LPS and rat with fever induced by dried yeast (P<0.05), inhibit inflammatory reaction of mice with ear swelling induced by dimethylbenzene and rat with toe swelling caused by albumen (P<0.05), and reduce the contents of PGE2 in the inflammatory tissue (P<0.05). Conclusion:FangFengGanMaogranules possess better effects of reliev-ing the fever and anti-inflammation.