CAJ | 학술논문

目的：自身对照比较Gd-EOB-DTPA 与Gd-DTPA 增强 MR 对肝硬化患者的肝动脉、门静脉和肝实质强化效果的差异。方法：回顾性分析35例肝硬化患者的Gd-EOB-DTPA与Gd-DTPA增强MR图像，计算肝总动脉、门静脉和肝实质的强化比率（PE）和肝总动脉、门静脉与肝实质的相对对比度（RC），并统计是否存在差异。结果：Gd-EOB-DTPA增强 MR肝总动脉、门静脉的平均PE明显低于Gd-DTPA（P＜0．05）。Gd-EOB-DTPA 的门脉期肝实质的平均PE 明显低于Gd-DTPA（P＜0．05）而动脉期肝实质的PE 值无明显差异（P＝0．1010）。肝总动脉、门静脉与肝实质的 RC 值 Gd-DTPA增强 MR略高于Gd-EOB-DTPA，但是无明显统计学差异（P 分别为0．3421和0．2389）。结论：肝硬化患者 Gd-EOB-DTPA增强 MR的肝血管和肝实质效果低于Gd-DTPA，Gd-EOB-DTPA的剂量需要进一步调整。
목적：자신대조비교Gd-EOB-DTPA 여Gd-DTPA 증강 MR 대간경화환자적간동맥、문정맥화간실질강화효과적차이。방법：회고성분석35례간경화환자적Gd-EOB-DTPA여Gd-DTPA증강MR도상，계산간총동맥、문정맥화간실질적강화비솔（PE）화간총동맥、문정맥여간실질적상대대비도（RC），병통계시부존재차이。결과：Gd-EOB-DTPA증강 MR간총동맥、문정맥적평균PE명현저우Gd-DTPA（P＜0．05）。Gd-EOB-DTPA 적문맥기간실질적평균PE 명현저우Gd-DTPA（P＜0．05）이동맥기간실질적PE 치무명현차이（P＝0．1010）。간총동맥、문정맥여간실질적 RC 치 Gd-DTPA증강 MR략고우Gd-EOB-DTPA，단시무명현통계학차이（P 분별위0．3421화0．2389）。결론：간경화환자 Gd-EOB-DTPA증강 MR적간혈관화간실질효과저우Gd-DTPA，Gd-EOB-DTPA적제량수요진일보조정。
Objective:To evaluate the differences of enhance effects of common hepatic artery (CHA),portal vein (PV)and hepatic parenchyma on dynamic contrast-enhanced (DCE)MRI by using gadolinium ethoxybenzyldiethylenetri-amine pentaacetic acid (Gd-EOB-DTPA)and gadolinium diethylenetriamine pentaacetic acid (Gd-DTPA)separately in the same cirrhotic patient.Methods:The enhanced MR images of liver in 35 cirrhotic patients obtained by using Gd-EOB-DTPA and Gd-DTPA separately in the same patient were reviewed.The percentage enhancement (PE)of CHA,PV and hepatic parenchyma and the relative contrast (RC)between CHA,PV and hepatic parenchyma were calculated and analyzed statisti-cally.Results:The mean PEs of CHA,PV were significantly lower for Gd-EOB-DTPA than Gd-DPTA (P<0.05).The mean PE of hepatic parenchyma at portal phase using Gd-EOB-DTPA was markedly lower than that using Gd-DPTA (P<0.05),whereas there was no significant difference of the mean PE of hepatic parenchyma at arterial phase (P= 0.1010). The RC values of CHA,PV and hepatic parenchyma using Gd-DTPA was slightly higher than that using Gd-EOB-DTPA, yet with no significant statistic difference (P= 0.3421 and 0.2389 respectively).Conclusion:Compared with Gd-DTPA,the enhance effect of Gd-EOB-GTPA was lower in hepatic vessels and hepatic parenchyma in patients with cirrhosis,adjustment of the dosage of Gd-EOB-GTPA should be considered.