CAJ | 학술논문

目的：探讨磁共振血管大小成像（VSI）在脑胶质瘤和脑膜瘤中的临床应用。方法：回顾性分析经组织病理证实的16例胶质瘤（低级别6例，高级别10例）和13例脑膜瘤的VSI图像，测量肿瘤实性部分的Q、fCBV、Nl、Nu和Ru值，比较高级与低级别胶质瘤、胶质瘤与脑膜瘤各测量值的差异。结果：低级别和高级别胶质瘤之间fCBV和Nu值有统计学差异（P＜0．05）；Q、Nl和Ru值无显著统计学差异。胶质瘤和脑膜瘤之间Ru值有统计学差异（P＜0．05）；Q，fCBV、Nl 和Nu值无显著统计学差异。结论：VSI可以反映微循环灌注的某些信息，在 MVD的无创性评估和高低级别胶质瘤的术前分级中有重要作用，从而更好的评估患者的预后和指导临床治疗，特别是抗血管治疗。
목적：탐토자공진혈관대소성상（VSI）재뇌효질류화뇌막류중적림상응용。방법：회고성분석경조직병리증실적16례효질류（저급별6례，고급별10례）화13례뇌막류적VSI도상，측량종류실성부분적Q、fCBV、Nl、Nu화Ru치，비교고급여저급별효질류、효질류여뇌막류각측량치적차이。결과：저급별화고급별효질류지간fCBV화Nu치유통계학차이（P＜0．05）；Q、Nl화Ru치무현저통계학차이。효질류화뇌막류지간Ru치유통계학차이（P＜0．05）；Q，fCBV、Nl 화Nu치무현저통계학차이。결론：VSI가이반영미순배관주적모사신식，재 MVD적무창성평고화고저급별효질류적술전분급중유중요작용，종이경호적평고환자적예후화지도림상치료，특별시항혈관치료。
Objective:To investigate the clinical application of vessel size imaging (VSI)in cerebral glioma and menin-gioma.Methods:The VSI data of histologically and pathologically proved cerebral tumors were retrospectively analysed,in-cluding 11 cases of gliomas (low grade 7,high grade 4)and 9 meningiomas.Q (MRI-measurable index),fCBV (cerebral blood volume fraction),Nl (the lower microvessel density bound),Nu (the upper microvessel density bound)and Ru (an upper bound on the mean vessel radius)values of the solid parts within the tumors were measured.The five values meas-ured were compared between high- and low-grade gliomas and between gliomas and meningiomas.Results:The fCBV and Nu values between low- and high-grade glioma s had statistically significant differences (P<0.05);The Q,Nl and Ru values had no statistically significant difference between them.The Ru values had statistically significant difference between glio-ma and meningioma group(P<0.05);the rest four measured values had no statistically significant differences.Conclusion:VSI can give some important information about microcirculation perfusion,plays an important role in noninvasively evalua-ting of MVD and grading gliomas before surgery,and thus can better assess the prognosis and guide clinical treatment,es-pecially anti-angiogenic therapy.