风湿病与关节炎
風濕病與關節炎
풍습병여관절염
Rheumatism and Arthritis
2014年
7期
25-27
,共3页
脊柱炎,强直性%补肾壮骨方%疗效
脊柱炎,彊直性%補腎壯骨方%療效
척주염,강직성%보신장골방%료효
spondylitis,ankylosing%Bushen Zhuanggu Formula%curative effect
目的：观察补肾壮骨方加减治疗强直性脊柱炎的疗效。方法：将192例强直性脊柱炎患者按照随机数字表法分为中药组和西药组，每组96例。中药组按证型再分为肾虚湿寒证组（A组）52例，给予补肾壮骨驱寒汤+西药安慰剂治疗；肾虚湿热证组（B组）44例，给补肾壮骨清化汤+西药安慰剂治疗。西药组按证型再分为肾虚湿寒证组（C组）49例，给予柳氮磺吡啶+中药安慰剂治疗；肾虚湿热证组（D组），47例，给予柳氮磺吡啶+中药安慰剂治疗。均治疗8周，观察统计各组患者治疗前后Bath AS总和指数（BAS-G）、Bath AS疾病活动指数（BASDAI）、Bath AS功能指数（BASFI）、夜间痛、脊柱痛、中医证候评分。以ASAS 20疗效评定标准进行疗效评定。结果：治疗后各组BAS-G、BASDAI、BASFI、夜间痛、脊柱痛、中医证候评分均较治疗前有所好转（P<0.05或P<0.01）。中药组有效率高于西药组（P<0.05）。结论：补肾壮骨方加减治疗强直性脊柱炎疗效显著，可为临床治疗强直性脊柱炎提供有效可靠的方法。
目的：觀察補腎壯骨方加減治療彊直性脊柱炎的療效。方法：將192例彊直性脊柱炎患者按照隨機數字錶法分為中藥組和西藥組，每組96例。中藥組按證型再分為腎虛濕寒證組（A組）52例，給予補腎壯骨驅寒湯+西藥安慰劑治療；腎虛濕熱證組（B組）44例，給補腎壯骨清化湯+西藥安慰劑治療。西藥組按證型再分為腎虛濕寒證組（C組）49例，給予柳氮磺吡啶+中藥安慰劑治療；腎虛濕熱證組（D組），47例，給予柳氮磺吡啶+中藥安慰劑治療。均治療8週，觀察統計各組患者治療前後Bath AS總和指數（BAS-G）、Bath AS疾病活動指數（BASDAI）、Bath AS功能指數（BASFI）、夜間痛、脊柱痛、中醫證候評分。以ASAS 20療效評定標準進行療效評定。結果：治療後各組BAS-G、BASDAI、BASFI、夜間痛、脊柱痛、中醫證候評分均較治療前有所好轉（P<0.05或P<0.01）。中藥組有效率高于西藥組（P<0.05）。結論：補腎壯骨方加減治療彊直性脊柱炎療效顯著，可為臨床治療彊直性脊柱炎提供有效可靠的方法。
목적：관찰보신장골방가감치료강직성척주염적료효。방법：장192례강직성척주염환자안조수궤수자표법분위중약조화서약조，매조96례。중약조안증형재분위신허습한증조（A조）52례，급여보신장골구한탕+서약안위제치료；신허습열증조（B조）44례，급보신장골청화탕+서약안위제치료。서약조안증형재분위신허습한증조（C조）49례，급여류담광필정+중약안위제치료；신허습열증조（D조），47례，급여류담광필정+중약안위제치료。균치료8주，관찰통계각조환자치료전후Bath AS총화지수（BAS-G）、Bath AS질병활동지수（BASDAI）、Bath AS공능지수（BASFI）、야간통、척주통、중의증후평분。이ASAS 20료효평정표준진행료효평정。결과：치료후각조BAS-G、BASDAI、BASFI、야간통、척주통、중의증후평분균교치료전유소호전（P<0.05혹P<0.01）。중약조유효솔고우서약조（P<0.05）。결론：보신장골방가감치료강직성척주염료효현저，가위림상치료강직성척주염제공유효가고적방법。
Objective:To observe the curative effect of modified Bushen Zhuanggu Decoction in the treatment of ankylosing spondylitis.Methods:192 cases of ankylosing spondylitis were randomly and equally divided into the traditional Chinese medicine (TCM) group and the Western medicine (WM) group. The TCM group according to the model were then divided into kidney deficiency and wet cold group(Group A),kidney deifciency and damp heat group(Group B).Group A 52 cases treated with Bushen Zhuanggu Quhan Decoction plus Western Placebo,group B 44 cases treated with Bushen Zhuanggu Qinghua Decoction plus Western Placebo.The WM group according to the model were then divided into kidney deficiency and wet cold group (Group C),kidney deficiency and damp heat group(Group D).Group C 49 cases treated with Sulfasalazine plus TCM Placebo,group D 47 cases treated with Sulfasalazine plus TCM Placebo.Each group were treated for 8 weeks,observing BAS-G,BASDAI,BASFI,night pain,spinal pain,and TCM syndrome score of the 4 groups before and after treatment.Efifcacy evaluation was carried out by ASAS20 efifcacy evaluation criteria.Results:The BAS-G, BASDAI,BASFI,night pain,spinal pain,and TCM syndrome score of all the groups improved after treatment (P<0.05 or P<0.01).The effective rate of the TCM group was higher than that of the WM group (P<0.05). Conclusion:The modified Bushen Zhuanggu Decoction had an obvious effect on the treatment of ankylosing spondylitis,reliable for clinical treatment.
