中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2014年
10期
1046-1049
,共4页
2型糖尿病%血管病变%黏附分子%细胞因子
2型糖尿病%血管病變%黏附分子%細胞因子
2형당뇨병%혈관병변%점부분자%세포인자
Type 2 diabetes%Vascular disease%Adhesion molecules%Cytokines
目的 探讨2型糖尿病(T2DM)患者血清黏附分子与细胞因子水平以及与血管病变的关系.方法 选择96例T2DM患者按照血管病变情况分为无血管病变组(28例)、微血管病变组(33例)、大血管病变组(35例),选择同期健康体检者30名作为对照组,ELISA法检测血清细胞间黏附分子1(ICAM-1)和血管细胞黏附分子1(VCAM-1),细胞因子包括白细胞介素6(IL-6)、肿瘤坏死因子α(TNF-α)和假性血友病因子(vWF)浓度,同时检测治疗半个月后T2DM患者黏附分子和细胞因子的表达.结果 与对照组比较,T2DM患者不同血管病变组ICAM-1、VCAM-1、IL-6和TNF-α水平都明显增高,差异有统计学意义(P均＜0.05),且随着患者血管病变的严重,其表达也有升高趋势,差异有统计学意义(P均＜0.05);治疗半个月后,患者血清ICAM-1、VCAM-1、IL-6和TNF-α水平显著性降低,差异具有统计学意义(t值分别为16.281、8.712、7.697、8.445,P均＜0.05),各指标分别从治疗前(505.34±56.42) μg/L,(570.85±59.54)μg/L,(94.51±18.04) ng/L,(70.57±18.34) ng/L降到治疗后(390.53±45.23) μg/L,(482.93±69.85) μg/L,(77.31±15.49) ng/L,(50.45±12.66) ng/L;T2DM患者血清ICAM-1、VCAM-1、IL-6及TNF-α水平与vWF的表达都呈明显的正相关(r值分别为0.482、0.453、0.576、0.534,P均＜0.05).结论 黏附分子和细胞因子共同参与了T2DM恶化以及血管病变的发生发展.
目的 探討2型糖尿病(T2DM)患者血清黏附分子與細胞因子水平以及與血管病變的關繫.方法 選擇96例T2DM患者按照血管病變情況分為無血管病變組(28例)、微血管病變組(33例)、大血管病變組(35例),選擇同期健康體檢者30名作為對照組,ELISA法檢測血清細胞間黏附分子1(ICAM-1)和血管細胞黏附分子1(VCAM-1),細胞因子包括白細胞介素6(IL-6)、腫瘤壞死因子α(TNF-α)和假性血友病因子(vWF)濃度,同時檢測治療半箇月後T2DM患者黏附分子和細胞因子的錶達.結果 與對照組比較,T2DM患者不同血管病變組ICAM-1、VCAM-1、IL-6和TNF-α水平都明顯增高,差異有統計學意義(P均＜0.05),且隨著患者血管病變的嚴重,其錶達也有升高趨勢,差異有統計學意義(P均＜0.05);治療半箇月後,患者血清ICAM-1、VCAM-1、IL-6和TNF-α水平顯著性降低,差異具有統計學意義(t值分彆為16.281、8.712、7.697、8.445,P均＜0.05),各指標分彆從治療前(505.34±56.42) μg/L,(570.85±59.54)μg/L,(94.51±18.04) ng/L,(70.57±18.34) ng/L降到治療後(390.53±45.23) μg/L,(482.93±69.85) μg/L,(77.31±15.49) ng/L,(50.45±12.66) ng/L;T2DM患者血清ICAM-1、VCAM-1、IL-6及TNF-α水平與vWF的錶達都呈明顯的正相關(r值分彆為0.482、0.453、0.576、0.534,P均＜0.05).結論 黏附分子和細胞因子共同參與瞭T2DM噁化以及血管病變的髮生髮展.
목적 탐토2형당뇨병(T2DM)환자혈청점부분자여세포인자수평이급여혈관병변적관계.방법 선택96례T2DM환자안조혈관병변정황분위무혈관병변조(28례)、미혈관병변조(33례)、대혈관병변조(35례),선택동기건강체검자30명작위대조조,ELISA법검측혈청세포간점부분자1(ICAM-1)화혈관세포점부분자1(VCAM-1),세포인자포괄백세포개소6(IL-6)、종류배사인자α(TNF-α)화가성혈우병인자(vWF)농도,동시검측치료반개월후T2DM환자점부분자화세포인자적표체.결과 여대조조비교,T2DM환자불동혈관병변조ICAM-1、VCAM-1、IL-6화TNF-α수평도명현증고,차이유통계학의의(P균＜0.05),차수착환자혈관병변적엄중,기표체야유승고추세,차이유통계학의의(P균＜0.05);치료반개월후,환자혈청ICAM-1、VCAM-1、IL-6화TNF-α수평현저성강저,차이구유통계학의의(t치분별위16.281、8.712、7.697、8.445,P균＜0.05),각지표분별종치료전(505.34±56.42) μg/L,(570.85±59.54)μg/L,(94.51±18.04) ng/L,(70.57±18.34) ng/L강도치료후(390.53±45.23) μg/L,(482.93±69.85) μg/L,(77.31±15.49) ng/L,(50.45±12.66) ng/L;T2DM환자혈청ICAM-1、VCAM-1、IL-6급TNF-α수평여vWF적표체도정명현적정상관(r치분별위0.482、0.453、0.576、0.534,P균＜0.05).결론 점부분자화세포인자공동삼여료T2DM악화이급혈관병변적발생발전.
Objective To explore the relationship of the levels of adhesion molecules and cytokines with vascular disease in patients with type 2 diabetes (T2DM).Methods Ninety-six T2DM patients were selected as case group and divided into non-vascular group (28 cases),micro-vascular group (33 cases) and major vascular group(35 cases) according to vascular disease.Meanwhile,30 healthy persons were selected as control group.Serum levels of serum soluble intercellular adhesion molecule-1 (ICAM-1),vascular cell adhesion molecule-1 (VCAM-1),interleukin-6 (IL-6),tumor necrosis factor-α (TNF-α) and yon willebrand factor (vWF) were determined by Enzyme-Linked Immuno Sorbent Assay (ELISA),and the expression of adhesion molecule and cytokines of patients with T2MD at 2 weeks after treatment.Results Compared with control group,the levels of ICAM-1,VCAM-1,TNF-α and IL-6 in all subgroup of T2DM patients were significantly elevated(P ＜ 0.05),and the levels showed an increasing trend with function deterioration (P ＜ 0.05).The levels of ICAM-1,VCAM-1,IL-6 and TNF-α in case group before treatment were (505.34 ± 56.42) μg/L,(570.85 ±59.54) μg/L,(94.51 ± 18.04) ng/L,(70.57 ± 18.34) ng/L respectively,significant different from those of after treatment ((390.53 ±45.23) μg/L,(482.93 ± 69.85) μg/L,(77.31 ± 15.49) ng/L,(50.45 ± 12.66) ng/L; t =16.281,8.712,7.697,8.445; P ＜ 0.05).There were significant positive correlation between ICAM-1,VCAM-1,IL-6,TNF-α and vWF in the case group(r =0.482,0.453,0.576,0.534 respectively,P ＜ 0.05).Conclusion Adhesion molecules and cytokines are take part in the process of the deterioration of T2DM and the occurrence of vascular disease.
