CAJ | 학술논문

目的：研究首发抑郁症患者治疗前后工作记忆变化。方法选取30例首发型抑郁症患者（患者组）以及与其人口学资料相匹配的30例健康对照组作为研究对象，采用字母2-Back任务进行工作记忆的测试。结果①患者组治疗前在正确率和反应时[（66．39±7．06）％；（1440．85±256．69）ms]均差于对照组[（91．39±7．54）％；（1153．92±282．35）ms]，差异有统计学意义（t＝-13．253，P＝0．00；t＝4．119，P＝0．00）；②患者组治疗后正确率（81．22±11．35）％要差于对照组（91．39±7．54）％，差异有统计学意义（t＝-4．085，P＜0．05）；③治疗后患者组正确率和反应时均有明显提高（t＝-6．710，P＜0．05；t＝4．150，P＜0．05）。结论抑郁症患者治疗后工作记忆功能明显提高，但未恢复到正常水平，这种损伤可能与中枢系统激活异常相关。
목적：연구수발억욱증환자치료전후공작기억변화。방법선취30례수발형억욱증환자（환자조）이급여기인구학자료상필배적30례건강대조조작위연구대상，채용자모2-Back임무진행공작기억적측시。결과①환자조치료전재정학솔화반응시[（66．39±7．06）％；（1440．85±256．69）ms]균차우대조조[（91．39±7．54）％；（1153．92±282．35）ms]，차이유통계학의의（t＝-13．253，P＝0．00；t＝4．119，P＝0．00）；②환자조치료후정학솔（81．22±11．35）％요차우대조조（91．39±7．54）％，차이유통계학의의（t＝-4．085，P＜0．05）；③치료후환자조정학솔화반응시균유명현제고（t＝-6．710，P＜0．05；t＝4．150，P＜0．05）。결론억욱증환자치료후공작기억공능명현제고，단미회복도정상수평，저충손상가능여중추계통격활이상상관。
Objective To explore the damaging traits of working memory function in first episode patients with depressive disorder before treatment and after treatmentl.Methods 30 patients were compared with matched 30 health controls completed the alphabet 2-Back Task that assessed the working memory function.Results ①Before treatment,Patients group with Accurate rate and reaction time of 2-back Test were significantly different with health controls [(66.39 ±7.06)%vs (91.39 ±7.54)%],[(1440.85 ±256.69)ms vs (1153.92 ± 282.35)ms](t=-13.253,P=0.00;t=4.119,P=0.00).②After treatment,Patients group with Accurate rate of2-back Test were signif-icantly different with health controls[(81.22 ±11.35)% vs (91.39 ±7.54)%](t=-4.085,P<0.05),③Accurate rate and reaction time of 2-back Test in patients group were significantly different before and after treatment (t=-6.710,P<0.05;t=4.150,P<0.05). Conclusion The working memory function improves after treatment in patients with first-episode depression,but does not reach health con-trols degree.The impairments may be related to activation abnormal in central nervous system.