CAJ | 학술논문

目的：分析大剂量奥美拉唑治疗老年胃溃疡合并出血的疗效。方法选择2009年6月至2012年6月我院收治的78例老年胃溃疡合并出血患者作为研究对象，随机分成两组各39例，观察组使用大剂量奥美拉唑治疗，对照组使用常规剂量的奥美拉唑进行治疗，比较两组的疗效以及并发症的发生情况。结果治疗后观察组患者的再次出血率明显低于对照组(P<0.05)；观察组患者治疗后总有效率显著高于对照组(P<0.05)。两组患者的并发症发生情况比较无显著差异(P>0.05)。结论采用大剂量奥美拉唑治疗老年胃溃疡合并出血患者，能有效提高患者的临床治疗效果，同时降低了再出血的风险，适合在临床推广应用。
목적：분석대제량오미랍서치료노년위궤양합병출혈적료효。방법선택2009년6월지2012년6월아원수치적78례노년위궤양합병출혈환자작위연구대상，수궤분성량조각39례，관찰조사용대제량오미랍서치료，대조조사용상규제량적오미랍서진행치료，비교량조적료효이급병발증적발생정황。결과치료후관찰조환자적재차출혈솔명현저우대조조(P<0.05)；관찰조환자치료후총유효솔현저고우대조조(P<0.05)。량조환자적병발증발생정황비교무현저차이(P>0.05)。결론채용대제량오미랍서치료노년위궤양합병출혈환자，능유효제고환자적림상치료효과，동시강저료재출혈적풍험，괄합재림상추엄응용。
Objective To analyze the curative effect of high-dose omeprazole in the treatment of elderly patients with gastric ulcer complicated with hemorrhage. Methods 78 cases of elderly patients with gastric ulcer complicated with hemorrhage in our hospital from June 2009 to June 2012 were selected as the research objects and randomly divided into two groups, with 39 cases in each group. Patients in the observation group were treated with high-dose omeprazole, while patients in the control group were treated with normal-dose omeprazole. The curative effect and complication were compared between two groups. Results The incidence of re-bleeding of observation group was significantly lower than that of control group (P<0.05). The total effective rate of observation group was 94.87%, significantly higher than 76.92%of control group (P <0.05), but there was no statistical difference between two groups in the incidence of complications (P>0.05). Conclusions High-doses of omeprazole for the treatment of elderly patients with gastric ulcer complicated with hemorrhage, can effectively improve the clinical curative effect, and reduce the incidence of re-bleeding, which is worthy of clinical promotion.