中国医药
中國醫藥
중국의약
CHINA MEDICINE
2013年
9期
1211-1213
,共3页
汤华%李健%黄智慧%任振强%宁锦平
湯華%李健%黃智慧%任振彊%寧錦平
탕화%리건%황지혜%임진강%저금평
缺血性心脏病心力衰竭%心脉隆注射液%QT间期离散度%临床疗效
缺血性心髒病心力衰竭%心脈隆註射液%QT間期離散度%臨床療效
결혈성심장병심력쇠갈%심맥륭주사액%QT간기리산도%림상료효
Ischemic heart disease heart failure%Xinmailong injection%QT interval dispersion%Clinica1 efficacy
目的 探讨心脉隆对缺血性心脏病心力衰竭患者的临床疗效及QT间期离散度的影响.方法 选择南京鼓楼医院集团仪征医院心内科缺血性心脏病心力衰竭患者80例,应用随机数字表法将其分为心脉隆组和对照组,各40例.心脉隆组在常规抗心力衰竭治疗基础上加用心脉隆注射液,对照组仅应用常规抗心力衰竭治疗.比较2组总有效率,观察并比较2组治疗前后左心室射血分数、N末端脑钠肽原、QT间期离散度的情况.结果 心脉隆组总有效率为77.5％ (31/40),明显高于对照组的62.5％ (25/40),差异有统计学意义(P＜0.05).治疗后,2组左心室射血分数[心脉隆组:(44.3±2.9)％；对照组:(40.9±3.1)％]较治疗前[心脉隆组:(36.8±3.3)％；对照组:(35.6±3.9)％]升高(P＜0.05),N末端脑钠肽原[心脉隆组:(281 ±86)ng/L;对照组:(390±93) ng/L]明显降低[心脉隆组:(521±ll9)ng/L;对照组:(509±112) ng/L](P＜0.05).心脉隆组治疗后QT间期离散度[(43±15) ms]明显低于治疗前[(56±15)ms] (P ＜0.05),而对照组治疗前后QT间期离散度[治疗前:(56±15)ms；治疗后:(56±15) ms]比较差异无统计学意义(P＞0.05).治疗后,心脉隆组的左心室射血分数、N末端脑钠肽原、QT间期离散度与对照组治疗后比较,差异有统计学意义(P＜0.05).心脉隆组3例治疗3～5d后出现口干、恶心症状,未做处理,自行缓解.结论 心脉隆注射液在改善缺血性心脏病心力衰竭患者心肌缺血的同时,还能增强心肌收缩力,改善心室舒张功能,增强心功能.
目的 探討心脈隆對缺血性心髒病心力衰竭患者的臨床療效及QT間期離散度的影響.方法 選擇南京鼓樓醫院集糰儀徵醫院心內科缺血性心髒病心力衰竭患者80例,應用隨機數字錶法將其分為心脈隆組和對照組,各40例.心脈隆組在常規抗心力衰竭治療基礎上加用心脈隆註射液,對照組僅應用常規抗心力衰竭治療.比較2組總有效率,觀察併比較2組治療前後左心室射血分數、N末耑腦鈉肽原、QT間期離散度的情況.結果 心脈隆組總有效率為77.5％ (31/40),明顯高于對照組的62.5％ (25/40),差異有統計學意義(P＜0.05).治療後,2組左心室射血分數[心脈隆組:(44.3±2.9)％；對照組:(40.9±3.1)％]較治療前[心脈隆組:(36.8±3.3)％；對照組:(35.6±3.9)％]升高(P＜0.05),N末耑腦鈉肽原[心脈隆組:(281 ±86)ng/L;對照組:(390±93) ng/L]明顯降低[心脈隆組:(521±ll9)ng/L;對照組:(509±112) ng/L](P＜0.05).心脈隆組治療後QT間期離散度[(43±15) ms]明顯低于治療前[(56±15)ms] (P ＜0.05),而對照組治療前後QT間期離散度[治療前:(56±15)ms；治療後:(56±15) ms]比較差異無統計學意義(P＞0.05).治療後,心脈隆組的左心室射血分數、N末耑腦鈉肽原、QT間期離散度與對照組治療後比較,差異有統計學意義(P＜0.05).心脈隆組3例治療3～5d後齣現口榦、噁心癥狀,未做處理,自行緩解.結論 心脈隆註射液在改善缺血性心髒病心力衰竭患者心肌缺血的同時,還能增彊心肌收縮力,改善心室舒張功能,增彊心功能.
목적 탐토심맥륭대결혈성심장병심력쇠갈환자적림상료효급QT간기리산도적영향.방법 선택남경고루의원집단의정의원심내과결혈성심장병심력쇠갈환자80례,응용수궤수자표법장기분위심맥륭조화대조조,각40례.심맥륭조재상규항심력쇠갈치료기출상가용심맥륭주사액,대조조부응용상규항심력쇠갈치료.비교2조총유효솔,관찰병비교2조치료전후좌심실사혈분수、N말단뇌납태원、QT간기리산도적정황.결과 심맥륭조총유효솔위77.5％ (31/40),명현고우대조조적62.5％ (25/40),차이유통계학의의(P＜0.05).치료후,2조좌심실사혈분수[심맥륭조:(44.3±2.9)％；대조조:(40.9±3.1)％]교치료전[심맥륭조:(36.8±3.3)％；대조조:(35.6±3.9)％]승고(P＜0.05),N말단뇌납태원[심맥륭조:(281 ±86)ng/L;대조조:(390±93) ng/L]명현강저[심맥륭조:(521±ll9)ng/L;대조조:(509±112) ng/L](P＜0.05).심맥륭조치료후QT간기리산도[(43±15) ms]명현저우치료전[(56±15)ms] (P ＜0.05),이대조조치료전후QT간기리산도[치료전:(56±15)ms；치료후:(56±15) ms]비교차이무통계학의의(P＞0.05).치료후,심맥륭조적좌심실사혈분수、N말단뇌납태원、QT간기리산도여대조조치료후비교,차이유통계학의의(P＜0.05).심맥륭조3례치료3～5d후출현구간、악심증상,미주처리,자행완해.결론 심맥륭주사액재개선결혈성심장병심력쇠갈환자심기결혈적동시,환능증강심기수축력,개선심실서장공능,증강심공능.
Objective To explore the effect of Xinmailong injection on QT dispersion and clinical efficacy in patients with ischemic heart failure.Methods Totally 80 patients with ischemic heart failure in our hospital were selected,and divided into Xinmailong group and control group with 40 cases in each group by random number table.Xinmailong group was given Xinmailong injection based on the conventional heart failure treatment,and control group was given conventional heart failure treatment.The total effective rate of two groups were compared,and left ventricular ejection fraction (LVEF),N terminal brain natriuretic peptide(NT-proBNP),QT dispersion (QTd) of two groups before and after treatment were observed and compared.Results The total effective rate of Xinmailong group was 77.5％ (31/40),and 62.5％ (25/40) in control group,there was significant difference (P ＜ 0.05).LVEF of two groups after treatment [Xinmailong group:(44.3 ± 2.9) ％ ; control group:(40.9 ± 3.1) ％] were higher compared with before treatment (P ＜ 0.05),NT-proBNP of two groups [Xinmailong group:(281± 86) ng/L;control group:(390 ± 93)ng/L] were decreased significantly than before treatment [Xinmailong group:(521 ± 119) ng/L; control group:(509 ± 112) ng/L] (P ＜ 0.05).QTd of Xinmailong group after treatment [(43 ±15)ms] was lower than before treatment [(56 ± 15)ms] (P ＜0.05),but there was no significant difference on QTd in pretherapy and post-treatment [pretherapy:(56 ± 15) ms ; post-treatment:(56 ± 15) ms] (P ＞ 0.05).After treatment,there were significant differences on LVEF,NT-proBNP,QTd between Xinmailong group and control group (P ＜ 0.05).Three cases of Xinmailong group felt dryness of the mouth and nausea after three to five days,and this symptoms alleviated by oneself without any treatment.Conclusions Xinmailong injection can improve myocardial ischemia and reduce the incidence of complex arrhythmias in patients with ischemic heart failure.Moreover,it can increase myocardial contracticity,improve ventricular diastolic function and enhance heart function.
