中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2014年
2期
209-211
,共3页
布地奈德气雾剂%特布他林气雾剂%支原体肺炎
佈地奈德氣霧劑%特佈他林氣霧劑%支原體肺炎
포지내덕기무제%특포타림기무제%지원체폐염
Pulmicort aerosol%Terbutaline aerosol%Mycoplasma pneumonia
目的 观察布地奈德气雾剂联合特布他林气雾剂治疗婴儿支原体肺炎(MP)的临床疗效.方法 以240例MP患儿为研究对象,根据治疗方法不同将240例患儿分为观察组和对照组,各120例,观察组给予布地奈德联合特布他林雾化吸入治疗,对照组给予布地奈德雾化吸入治疗.比较两组免疫学指标免疫球蛋白G(IgG)、免疫球蛋白E(IgE)及TNF-α水平、主要临床症状及疗效.结果 与治疗前比较,两组IgG、IgE、TNF-α水平,IgG明显升高,IgE、TNF-α水平明显降低,差异均具有统计学意义(t=19.965、10.780、3.468、6.002、5.440、4.885,均P＜0.05),且观察组明显优于对照组(=13.920、4.523、2.729,均P＜0.05)；观察组体温、喘憋、发绀、咳嗽及肺部啰音等临床症状缓解时间均明显短于对照组(t=2.991、6.034、4.623、8.562、7.113,均P＜0.05),显效率(93.3％)显著高于对照组(79.2％)(x2=8.140,P＜0.05)；两组均无明显不良反应.结论 布地奈德、特布他林雾化吸入治疗婴儿支原体肺炎,临床症状缓解快,疗效好,不良反应少,值得临床推广.
目的 觀察佈地奈德氣霧劑聯閤特佈他林氣霧劑治療嬰兒支原體肺炎(MP)的臨床療效.方法 以240例MP患兒為研究對象,根據治療方法不同將240例患兒分為觀察組和對照組,各120例,觀察組給予佈地奈德聯閤特佈他林霧化吸入治療,對照組給予佈地奈德霧化吸入治療.比較兩組免疫學指標免疫毬蛋白G(IgG)、免疫毬蛋白E(IgE)及TNF-α水平、主要臨床癥狀及療效.結果 與治療前比較,兩組IgG、IgE、TNF-α水平,IgG明顯升高,IgE、TNF-α水平明顯降低,差異均具有統計學意義(t=19.965、10.780、3.468、6.002、5.440、4.885,均P＜0.05),且觀察組明顯優于對照組(=13.920、4.523、2.729,均P＜0.05)；觀察組體溫、喘憋、髮紺、咳嗽及肺部啰音等臨床癥狀緩解時間均明顯短于對照組(t=2.991、6.034、4.623、8.562、7.113,均P＜0.05),顯效率(93.3％)顯著高于對照組(79.2％)(x2=8.140,P＜0.05)；兩組均無明顯不良反應.結論 佈地奈德、特佈他林霧化吸入治療嬰兒支原體肺炎,臨床癥狀緩解快,療效好,不良反應少,值得臨床推廣.
목적 관찰포지내덕기무제연합특포타림기무제치료영인지원체폐염(MP)적림상료효.방법 이240례MP환인위연구대상,근거치료방법불동장240례환인분위관찰조화대조조,각120례,관찰조급여포지내덕연합특포타림무화흡입치료,대조조급여포지내덕무화흡입치료.비교량조면역학지표면역구단백G(IgG)、면역구단백E(IgE)급TNF-α수평、주요림상증상급료효.결과 여치료전비교,량조IgG、IgE、TNF-α수평,IgG명현승고,IgE、TNF-α수평명현강저,차이균구유통계학의의(t=19.965、10.780、3.468、6.002、5.440、4.885,균P＜0.05),차관찰조명현우우대조조(=13.920、4.523、2.729,균P＜0.05)；관찰조체온、천별、발감、해수급폐부라음등림상증상완해시간균명현단우대조조(t=2.991、6.034、4.623、8.562、7.113,균P＜0.05),현효솔(93.3％)현저고우대조조(79.2％)(x2=8.140,P＜0.05)；량조균무명현불량반응.결론 포지내덕、특포타림무화흡입치료영인지원체폐염,림상증상완해쾌,료효호,불량반응소,치득림상추엄.
Objective To observe the curative effect of pulmicort aerosol combined with terbutaline aerosol in the treatment of infants with mycoplasma pneumonia (MP).Methods 240 children with MP were selected and according to the different treatment method,they were divided into the observation group and control group.120 cases in the observation group were treated with pulmicort combined with terbutaline inhalation therapy.120 cases in the control group received budesonide inhalation therapy.Immunological parameters of IgG,IgE and TNF-α level,the main clinical symptoms and clinical efficacy were compared between the two groups.Results Compared with before treatment,IgG significantly increased,IgE and TNF-α level significantly decreased after treatment in the two groups,the differences were statistically significant (t =19.965,10.780,3.468,6.002,5.440,4.885,all P ＜ 0.05).And those in the observation group were better than the control group (t =13.920,4.523,2.729,all P ＜ 0.05).The remis sion time of clinical symptoms such as body temperature,wheezing,cyanosis,cough and pulmonary rales in the observation group were significantly shorter than those of the control group (t =2.991,6.034,4.623,8.562,7.113,all P ＜ 0.05).The obvious effective rate of the observation group was 93.3％,which was higher than 79.2％ of the control group (x2 =8.140,P ＜ 0.05).There were no significant adverse reactions in two groups.Conclusion Budesonide combined with terbutaline atomization inhalation in the treatment of infants with mycoplasma pneumonia has short remission time of clinical symptoms,good efficacy and less adverse reactions,it is worthy of promotion.
