CAJ | 학술논문

目的：研究血塞通注射液对急性脑梗死患者CD62P分子表达的影响。方法将入选的128例急性脑梗死患者随机分为两组，每组64例，对照组按照指南给予标准化治疗，干预组在标准治疗的基础上联合使用血塞通注射液。两组均在入院时和治疗后12 d检测血清CD62P分子和血小板膜CD62P分子的水平。结果两组患者急诊入院时血清CD62P分子水平比较差异无统计学意义（ t=0.88，P﹥0.05），血小板膜CD62P分子水平比较差异无统计学意义（ t=0.43，P﹥0.05）；治疗后12 d，两组血清CD62P分子水平比较差异有统计学意义（ t=4.91，P﹤0.05），血小板膜CD62P分子水平比较差异有统计学意义（ t=3.61，P﹤0.05）。结论血塞通注射液能明显降低急性脑梗死时患者的血清和血小板膜CD62P分子水平，但是对于改善脑梗死患者的预后及病情转归还需要进一步研究。
목적：연구혈새통주사액대급성뇌경사환자CD62P분자표체적영향。방법장입선적128례급성뇌경사환자수궤분위량조，매조64례，대조조안조지남급여표준화치료，간예조재표준치료적기출상연합사용혈새통주사액。량조균재입원시화치료후12 d검측혈청CD62P분자화혈소판막CD62P분자적수평。결과량조환자급진입원시혈청CD62P분자수평비교차이무통계학의의（ t=0.88，P﹥0.05），혈소판막CD62P분자수평비교차이무통계학의의（ t=0.43，P﹥0.05）；치료후12 d，량조혈청CD62P분자수평비교차이유통계학의의（ t=4.91，P﹤0.05），혈소판막CD62P분자수평비교차이유통계학의의（ t=3.61，P﹤0.05）。결론혈새통주사액능명현강저급성뇌경사시환자적혈청화혈소판막CD62P분자수평，단시대우개선뇌경사환자적예후급병정전귀환수요진일보연구。
Objective To study the effect of Xuesaitong injection on CD62P molecular level in acute cerebral infarction pa-tients. Methods One hundred and twenty-eight patients were randomly divided into two groups,64 cases in control group were given standardized treatment according to the guideline,and 64 cases in intervention group were given Xuesaitong injection on the basis of standard therapy. The serum and platelet membrane CD62P levels on admission and after 12 days of treatment of the two groups were dete cted. Results The serum CD62P molecular levels of the two groups had no significant difference on admiscion (t=0. 88,P﹥0. 05),and the platelet membrane CD62P levels of the two groups had no significant difference on admission (t=0. 43,P﹥0. 05);After 12 days of treatment,the serum levels of CD62P molecular had significant difference between the two groups( t =4. 91,P ﹤0. 05 ),and the platelet membrane CD62P levels of the two group were significantly different (t=3. 61,P﹤0. 05). Conclusion Xuesaitong injection can significantly reduce the levels of serum and platelet membrane CD62P molecular expression,but further study is needed for improving the prognosis of patients with acute cerebral infarction and the progression.