中国血液流变学杂志
中國血液流變學雜誌
중국혈액류변학잡지
CHINESE JOURNAL OF HEMORHEOLOGY
2014年
1期
34-36
,共3页
右室流出道重建%动物模型%交叉循环
右室流齣道重建%動物模型%交扠循環
우실류출도중건%동물모형%교차순배
right ventricular outflow tract reconstruction%animal model%cross circulation
目的：在交叉循环下建立动物模型，为进一步研究适宜材料制备的右室流出道重建带瓣肺动脉管道提供实验动物模型支持。方法将比格犬随机分为2组，A组为模型犬组，用于建立右室流出道重建模型；B组为泵犬组，用于建立交叉循环后对A组提供心肺支持。交叉循环建立成功后，切开模型犬肺动脉，吸引器吸引血少许后，基本维持无血环境，证实能够进行右室流出道重建的相关操作，处死泵犬，模型犬关胸后，常规饲养。结果共使用5对比格犬建立交叉循环，1对因主动脉插管过程中主动脉撕裂，当场死亡，余4对均成功建立交叉循环犬动物模型，其中1只模型犬术后3d死于失血性休克，另外3只存活1周后处死。结论可以通过比格犬建立交叉循环动物模型，为研究各种适宜材料制备的右室流出道重建带瓣肺动脉管道提供模型支持。
目的：在交扠循環下建立動物模型，為進一步研究適宜材料製備的右室流齣道重建帶瓣肺動脈管道提供實驗動物模型支持。方法將比格犬隨機分為2組，A組為模型犬組，用于建立右室流齣道重建模型；B組為泵犬組，用于建立交扠循環後對A組提供心肺支持。交扠循環建立成功後，切開模型犬肺動脈，吸引器吸引血少許後，基本維持無血環境，證實能夠進行右室流齣道重建的相關操作，處死泵犬，模型犬關胸後，常規飼養。結果共使用5對比格犬建立交扠循環，1對因主動脈插管過程中主動脈撕裂，噹場死亡，餘4對均成功建立交扠循環犬動物模型，其中1隻模型犬術後3d死于失血性休剋，另外3隻存活1週後處死。結論可以通過比格犬建立交扠循環動物模型，為研究各種適宜材料製備的右室流齣道重建帶瓣肺動脈管道提供模型支持。
목적：재교차순배하건립동물모형，위진일보연구괄의재료제비적우실류출도중건대판폐동맥관도제공실험동물모형지지。방법장비격견수궤분위2조，A조위모형견조，용우건립우실류출도중건모형；B조위빙견조，용우건입교차순배후대A조제공심폐지지。교차순배건립성공후，절개모형견폐동맥，흡인기흡인혈소허후，기본유지무혈배경，증실능구진행우실류출도중건적상관조작，처사빙견，모형견관흉후，상규사양。결과공사용5대비격견건입교차순배，1대인주동맥삽관과정중주동맥시렬，당장사망，여4대균성공건입교차순배견동물모형，기중1지모형견술후3d사우실혈성휴극，령외3지존활1주후처사。결론가이통과비격견건입교차순배동물모형，위연구각충괄의재료제비적우실류출도중건대판폐동맥관도제공모형지지。
Objective To construct animal model of cross-circulation, and provide the experimental animal model for further study of suitable materials to make valved pulmonary conduit in the right ventricular outflow tract reconstruction. Methods We took Beagle dogs as experimental subjects and they were randomly divided into two groups, one as model group, used for the right ventricular outflow tract reconstruction, another as a pump group, used to provide cardiopulmonary support after the cross-circulation was constructed. When the cross-circulation was constructed, we incised the pulmonary artery of the model dog, using suction to suck up little blood, mainly maintaining no-blood environment. This proved that we could reconstruct the right ventricular outflow tract on the model dog. Then we executed the pump dog, closed the chest of the model dog and breed it. Results Using five pairs of beagle dogs to establish cross circulation in all, one pair died on the spot, due to aortic tearing during the aortic cannulation. The rest four pairs successfully set up cross circulation animal models. And one died of hemorrhagic shock 3 days later, another three dogs survived and put to death after 1 week. Conclusion Using Beagle dogs to construct cross-circulation animal models is feasible and it can provide modeling support for comprehensive study of suitable materials to make valved pulmonary conduit in the right ventricular outflow tract reconstruction.
