CAJ | 학술논문

目的：研究阻塞性睡眠呼吸暂停综合征(obstructive sleep apnea-hypopnea syndrome,OSAHS)与肾损伤的相关性。方法计算机检索 PubMed、EMbase、Web of science、Cochrane library、CNKI、CBM、VIP、wanfangdata 电子数据库,并辅助手工检索,检索时间截至2013年12月,收集 OSAHS 与肾损伤相关的队列研究和病例对照研究。由2位评价员独立进行质量评价、数据提取并交叉核对后,采用 RevMan 5.2软件进行 meta 分析。结果共纳入6个病例对照研究,包括659例研究对象。Meta 分析结果显示,轻、中、重度 OSAHS 患者血清胱抑素 C、尿 N-乙酰-β-D 氨基葡萄糖苷均高于对照组；中、重度 OSAHS 患者血清肌酐、尿γ-谷氨酰转移酶均高于对照组；重度 OSAHS 患者血清尿素氮(BUN)高于对照组(P <0.05)。结论 OSAHS 与肾损伤相关。
목적：연구조새성수면호흡잠정종합정(obstructive sleep apnea-hypopnea syndrome,OSAHS)여신손상적상관성。방법계산궤검색 PubMed、EMbase、Web of science、Cochrane library、CNKI、CBM、VIP、wanfangdata 전자수거고,병보조수공검색,검색시간절지2013년12월,수집 OSAHS 여신손상상관적대렬연구화병례대조연구。유2위평개원독립진행질량평개、수거제취병교차핵대후,채용 RevMan 5.2연건진행 meta 분석。결과공납입6개병례대조연구,포괄659례연구대상。Meta 분석결과현시,경、중、중도 OSAHS 환자혈청광억소 C、뇨 N-을선-β-D 안기포도당감균고우대조조；중、중도 OSAHS 환자혈청기항、뇨γ-곡안선전이매균고우대조조；중도 OSAHS 환자혈청뇨소담(BUN)고우대조조(P <0.05)。결론 OSAHS 여신손상상관。
Objective To assess the correlation between obstructive sleep apnea-hypopnea syndrome(OSAHS) and renal damage.Methods Such databases as PubMed,EMbase,Web of science,Cochrane library,CNKI,CBM,VIP, wanfangdata electronic databases aided with manual search were screened up to December 2013 for literatures including case control study and cohort study about the correlation between OSAHS and renal injury.Two reviewers independently performed data extraction,quality evaluation and cross check,and Meta analysis was performed with RevMan 5.2 software.Results A total of six case control studies were involved,including 659 cases.Meta analysis showed that the levels of serum cystatin C,N-acetyl-beta-D-glucosamidase in light,medium,severe OSAHS patients were higher than those in the control group;the levels of serum serum creatinine,gamma glutamyl transferase in medium,severe OSAHS patients were higher than those in the control group;the levels of serum blood urea nitrogen in severe OSAHS patients were higher than those in the control group(P <0.05 ).Conclusion OSAHS is significantly related with renal damage.