CAJ | 학술논문

目的：观察注射用七叶皂苷钠联合地塞米松磷酸钠注射液对亚急性甲状腺炎的临床疗效。方法将85例亚急性甲状腺炎患者随机分为2组，对照组42例予地塞米松磷酸钠注射液甲状腺局部注射，治疗组43例在对照组治疗基础上加注射用七叶皂苷钠静脉滴注。2组治疗4周后观察甲状腺疼痛、触痛缓解时间及甲状腺肿胀消失时间，检测2组治疗前后血清三碘甲状腺原氨酸（T3）、甲状腺素（T4）及超敏促甲状腺激素（S-TSH）水平。结果治疗组治愈率（90．70％）高于对照组（66．67％，P＜0．05）；与对照组比较治疗组甲状腺疼痛、触痛缓解时间、甲状腺肿胀消失时间及疗程短，复发率低（P＜0．05）。2组治疗后T3、T4及S-TSH治疗组水平与本组治疗前比较均明显改善（P＜0．05），但组间比较差异无统计意义（P＞0．05）。结论注射用七叶皂苷钠和地塞米松磷酸钠注射液联合治疗亚急性甲状腺炎可能存在协同作用，疗效确切。
목적：관찰주사용칠협조감납연합지새미송린산납주사액대아급성갑상선염적림상료효。방법장85례아급성갑상선염환자수궤분위2조，대조조42례여지새미송린산납주사액갑상선국부주사，치료조43례재대조조치료기출상가주사용칠협조감납정맥적주。2조치료4주후관찰갑상선동통、촉통완해시간급갑상선종창소실시간，검측2조치료전후혈청삼전갑상선원안산（T3）、갑상선소（T4）급초민촉갑상선격소（S-TSH）수평。결과치료조치유솔（90．70％）고우대조조（66．67％，P＜0．05）；여대조조비교치료조갑상선동통、촉통완해시간、갑상선종창소실시간급료정단，복발솔저（P＜0．05）。2조치료후T3、T4급S-TSH치료조수평여본조치료전비교균명현개선（P＜0．05），단조간비교차이무통계의의（P＞0．05）。결론주사용칠협조감납화지새미송린산납주사액연합치료아급성갑상선염가능존재협동작용，료효학절。
Objective To investigate the curative effect of sodium aescine combined with intrathyroidal in-jection of dexamethasone on subacute thyroiditis .Methods 85 patients with subacute thyroiditis were divided ran-domly into two groups .43 patients in treatment group were treated with Sodium aescine combined with intrathyroidal injection of dexamethasone (5 mg, one per day, and then once per week).42 patients in control group received intra-thyroidal injection of dexamethasone (5 mg, one per day, and then once per week.).After four weeks of treatment thyroid pain , tenderness pain relief time and thyroid gland swelling disappeared time were observed .The levels of T 3 , T4 and S-TSH were detected before and after treatment .Results The treatment group cure rate (90.70%) was higher than that in the control group (66.67%, P<0.05).thyroid pain, tenderness pain relief time and thyroid gland swelling disappeared time were shorten , recurrence rate was lower ( P <0.05).Conclusion Sodium aescine combined with intrathyroidal injection of dexamethasone is more effective than intrathyroidal injection of dexametha -sone alone in treatment of subacute thyroiditis .