河北中医
河北中醫
하북중의
HEBEI JORNAL OF TRADITIONAL CHINESE MEDICINE
2014年
8期
1196-1198
,共3页
痴呆,血管性%针灸疗法%针刺疗法
癡呆,血管性%針灸療法%針刺療法
치태,혈관성%침구요법%침자요법
Vascular Dementia%Acupuncture and moxibustion therapy%Acupuncture therapy
目的:观察针刺疗法对血管性痴呆( VD)患者生活状态及血浆乙酰胆碱酯酶活性的影响。方法将120例VD患者随机分为2组。治疗组60例予针刺治疗,对照组60例予石杉碱甲治疗。2组均1个月为1个疗程,3个疗程后统计临床疗效,并用改良Ellman比色法检测治疗前后2组血浆乙酰胆碱酯酶( AchE)的活性、简易智力状态检查量表( MMSE)评分和日常生活自理能力表( ADL)评分情况,应用肌电诱发电位仪对2组治疗前后事件相关电位P300潜伏期、波幅进行检测。结果治疗组总有效率80.00%,对照组总有效率51.67%,治疗组疗效优于对照组(P<0.05);2组治疗后MMSE、ADL评分与本组治疗前比较均改善(P<0.01),且治疗组治疗后MMSE、ADL评分改善优于对照组(P<0.05);2组治疗后血浆AchE水平较本组治疗前均升高(P<0.01),且治疗组治疗后血浆AchE水平升高优于对照组治疗后(P<0.05)。2组治疗后事件相关电位P300潜伏期缩短( P<0.05),波幅升高( P<0.05)。结论针刺治疗VD疗效确切,其机制与升高血浆 AchE水平相关。
目的:觀察針刺療法對血管性癡呆( VD)患者生活狀態及血漿乙酰膽堿酯酶活性的影響。方法將120例VD患者隨機分為2組。治療組60例予針刺治療,對照組60例予石杉堿甲治療。2組均1箇月為1箇療程,3箇療程後統計臨床療效,併用改良Ellman比色法檢測治療前後2組血漿乙酰膽堿酯酶( AchE)的活性、簡易智力狀態檢查量錶( MMSE)評分和日常生活自理能力錶( ADL)評分情況,應用肌電誘髮電位儀對2組治療前後事件相關電位P300潛伏期、波幅進行檢測。結果治療組總有效率80.00%,對照組總有效率51.67%,治療組療效優于對照組(P<0.05);2組治療後MMSE、ADL評分與本組治療前比較均改善(P<0.01),且治療組治療後MMSE、ADL評分改善優于對照組(P<0.05);2組治療後血漿AchE水平較本組治療前均升高(P<0.01),且治療組治療後血漿AchE水平升高優于對照組治療後(P<0.05)。2組治療後事件相關電位P300潛伏期縮短( P<0.05),波幅升高( P<0.05)。結論針刺治療VD療效確切,其機製與升高血漿 AchE水平相關。
목적:관찰침자요법대혈관성치태( VD)환자생활상태급혈장을선담감지매활성적영향。방법장120례VD환자수궤분위2조。치료조60례여침자치료,대조조60례여석삼감갑치료。2조균1개월위1개료정,3개료정후통계림상료효,병용개량Ellman비색법검측치료전후2조혈장을선담감지매( AchE)적활성、간역지력상태검사량표( MMSE)평분화일상생활자리능력표( ADL)평분정황,응용기전유발전위의대2조치료전후사건상관전위P300잠복기、파폭진행검측。결과치료조총유효솔80.00%,대조조총유효솔51.67%,치료조료효우우대조조(P<0.05);2조치료후MMSE、ADL평분여본조치료전비교균개선(P<0.01),차치료조치료후MMSE、ADL평분개선우우대조조(P<0.05);2조치료후혈장AchE수평교본조치료전균승고(P<0.01),차치료조치료후혈장AchE수평승고우우대조조치료후(P<0.05)。2조치료후사건상관전위P300잠복기축단( P<0.05),파폭승고( P<0.05)。결론침자치료VD료효학절,기궤제여승고혈장 AchE수평상관。
Objective To observe the effect of acupuncture therapy on living conditions and acetyl cholines -terase activity in plasma of patients with vascular dementia ( VD) .Methods 120 VD patients were randomly divid-ed into two groups .Treatment group received acupuncture therapy .Control group received huperzine a .The course was a month in two groups.The clinical effect was evaluated after three courses .Plasma AchE activity,MMSE score,ADL score and latency,amplitude detection of event -related potentials P300 were finished.Results The total effective rate in treatment group (80.00%)was superior to than in control group (51.67%,P<0.05).MMSE and ADL after treatment were improved in two groups ( P<0.01) .The improvement in treatment group was superior to that in control group (P<0.05).The increase of Plasma AchE level in treatment group was superior to that in control group (P<0.05).The event related potential P300 showed shortened latency ( P <0.05)and higher amplitude ( P <0.05). Conclusion Acupuncture therapy has exactly curative effect on the treatment of VD ,its mechanism is associated with elevated plasma levels of AchE .