CAJ | 학술논문

目的：探讨单用胺碘酮或联用三七总皂甙对阵发性房颤（ PAF ）患者P波离散度（ Pd ）和超敏C-反应蛋白（ hs-CRP）的影响。方法60例PAF患者随机分为研究组30例（三七总皂甙联用胺碘酮）与对照组30例（单用胺碘酮）。随访6个月，观察PAF复发情况，测定治疗前及治疗6个月后Pd及hs-CRP水平。结果在治疗6个月后，Kaplan-Meier分析显示研究组窦性心律维持率显著高于对照组（ P＜0．05）；治疗后研究组Pd、hs-CRP水平明显低于对照组（ P＜0．05）。结论三七总皂甙联用胺碘酮较单用胺碘酮可明显减少房颤复发，降低PAF患者Pd和hs-CRP水平。
목적：탐토단용알전동혹련용삼칠총조대대진발성방전（ PAF ）환자P파리산도（ Pd ）화초민C-반응단백（ hs-CRP）적영향。방법60례PAF환자수궤분위연구조30례（삼칠총조대련용알전동）여대조조30례（단용알전동）。수방6개월，관찰PAF복발정황，측정치료전급치료6개월후Pd급hs-CRP수평。결과재치료6개월후，Kaplan-Meier분석현시연구조두성심률유지솔현저고우대조조（ P＜0．05）；치료후연구조Pd、hs-CRP수평명현저우대조조（ P＜0．05）。결론삼칠총조대련용알전동교단용알전동가명현감소방전복발，강저PAF환자Pd화hs-CRP수평。
Objective To explore the effect of amiodarone alone or amiodarone in combination with Panax notoginsenosides(PNS) on P wave dispersion(Pd) and high sensitivity C-reactive protein(hs-CRP) in patients with paroxysmal atrial fibrillation (PAF).Methods Sixty PAF patients were randomly divided into study group (PNS combined with amiodarone) and control group(amiodarone alone),with 30 cases in each group.The follow-up lasted for 6 months.The recurrence of PAF was observed ,and the Pd and hs-CRP level were detected before and 6 months after treatment .Results Six months after treatment ,the Kaplan-Meier survival analysis suggested that the rate of sinus rhythm maintenance in the study group was significantly higher than that in the control group ( P<0.05) .The Pd and hs-CRP level in the study group were significantly lower than those in the control group after treatment (P<0.05).Conclusion Compared with amiodarone alone,Panax notoginsenosides combined with amiodarone can significantly reduce the recurrence of atrial fibrillation , decrease the Pd and hs-CPR level in PAF patients .