CAJ | 학술논문

目的：探讨脐血S100B蛋白对围产儿脑损伤早期诊断和监测的临床价值。方法233例新生儿，其中阴道分娩窒息组60例，剖宫产窒息组55例，阴道分娩健康组65例，剖宫产健康组53例；比较出生1 min Apgar评分＞7分组（213例）与≤7分组（20例）的脐血S100B蛋白水平；对宫内窘迫、窒息的115例围产儿进行影像学检查，确诊为缺氧缺血性脑病（HIE）围产儿75例与非HIE 40例采用酶联免疫吸附试验检测各组脐血 S100B蛋白水平，并对结果进行对比分析。结果脐血 S100B 蛋白水平阴道分娩窒息组为（0．31±0．08）μg/L、剖宫产窒息组为（0．17±0．07）μg/L，明显高于阴道分娩健康组的（0．08±0．03）μg/L 及剖宫产健康组的（0．08±0．04）μg/L （P＜0．01）；出生1 min Apgar 评分＞7分组脐血 S100B 蛋白水平为（0．16±0．14）μg/L，≤7分组为（0．20±0．14）μg/L，两者差异无统计学意义（P＞0．05）；HIE组S100B蛋白水平为（0．30±0．08）μg/L，显著高于非HIE组的（0．13±0．05）μg/L（P＜0．01）。结论新生儿脐血S100B蛋白浓度对早期诊断围产儿脑损伤有重要的临床价值。
목적：탐토제혈S100B단백대위산인뇌손상조기진단화감측적림상개치。방법233례신생인，기중음도분면질식조60례，부궁산질식조55례，음도분면건강조65례，부궁산건강조53례；비교출생1 min Apgar평분＞7분조（213례）여≤7분조（20례）적제혈S100B단백수평；대궁내군박、질식적115례위산인진행영상학검사，학진위결양결혈성뇌병（HIE）위산인75례여비HIE 40례채용매련면역흡부시험검측각조제혈 S100B단백수평，병대결과진행대비분석。결과제혈 S100B 단백수평음도분면질식조위（0．31±0．08）μg/L、부궁산질식조위（0．17±0．07）μg/L，명현고우음도분면건강조적（0．08±0．03）μg/L 급부궁산건강조적（0．08±0．04）μg/L （P＜0．01）；출생1 min Apgar 평분＞7분조제혈 S100B 단백수평위（0．16±0．14）μg/L，≤7분조위（0．20±0．14）μg/L，량자차이무통계학의의（P＞0．05）；HIE조S100B단백수평위（0．30±0．08）μg/L，현저고우비HIE조적（0．13±0．05）μg/L（P＜0．01）。결론신생인제혈S100B단백농도대조기진단위산인뇌손상유중요적림상개치。
Objective To investigate the clinical significance of S 100 B protein in umbilical cord blood for early diagnosis and monitoring of perinatal brain injury .Methods All of the 233 neonates were divided into 4 groups . Sixty neonates of vaginal delivery with asphyxia in group A ,55 neonates of cesarean delivery with asphyxia in group B , 65 neonates of vaginal delivery without asphyxia in group C ,and 53 neonates of cesarean delivery without asphyxia in group D.The levels of S100B protein between groups of Apgar score 1 minute after delivery >7 and≤7 were compared.Imaging studies were performed in the 115 neonates with intrauterine asphyxia .Enzyme-linked immunosorbent assay ( ELISA ) was used to detect the level of S 100 B protein in umbilical cord blood in 75 neonates with confirmed hypoxic ischemic encephalopathy ( HIE) and 40 neonates without HIE ,and a comparative analysis was performed .Results The levels of S100B protein in umbilical cord blood in group A [(0.31 ±0.08)μg/L],group B[(0.17 ±0.07)μg/L] were significantly higher than those in group C [(0.08 ±0.03)μg/L],group D[(0.08 ±0.04)μg/L,P<0.01].The levels of S100 B protein showed no significant difference between groups of Apgar score 1 minute after delivery >7 and ≤7[(0.16 ±0.14)μg/L vs.(0.20 ±0.14)μg/L,P>0.05].The level of S100B protein in HIE group was significantly higher than that in non-HIE group[(0.30 ±0.08)μg/L vs.(0.13 ±0.05)μg/L,P<0.01].Conclusion The detection of S100B protein in perinatal cord blood plays an important role in the early diagnosis of perinatal brain injury.