CAJ | 학술논문

N-异丙基丙烯酰胺（NIPAM）类水凝胶是典型的温敏水凝胶，通常含有亲水性酰胺基和疏水性异丙基，具有随温度变化而发生可逆溶胀/收缩的特殊性质，作为一种新型的智能材料得到广泛的应用。本文主要论述了NIPAM 类疏水改性温敏水凝胶的合成，在骨架中引入疏水单体可以改善其疏水特性，同时提高其温度敏感性，使其在药物释放、物质分离及生物医用材料等领域具有独特的应用价值。目前对疏水改性温敏水凝胶的理论研究尚浅，仍需拓展其在实际方面的应用，今后可考虑改善疏水单体的官能团结构提高疏水性能，合成更具温度响应性和环境友好性的智能温敏水凝胶，拓展其在催化、水处理、生物化工等领域的广泛应用。
N-이병기병희선알（NIPAM）류수응효시전형적온민수응효，통상함유친수성선알기화소수성이병기，구유수온도변화이발생가역용창/수축적특수성질，작위일충신형적지능재료득도엄범적응용。본문주요논술료NIPAM 류소수개성온민수응효적합성，재골가중인입소수단체가이개선기소수특성，동시제고기온도민감성，사기재약물석방、물질분리급생물의용재료등영역구유독특적응용개치。목전대소수개성온민수응효적이론연구상천，잉수탁전기재실제방면적응용，금후가고필개선소수단체적관능단결구제고소수성능，합성경구온도향응성화배경우호성적지능온민수응효，탁전기재최화、수처리、생물화공등영역적엄범응용。
N-isopropyl acrylamide (NIPAM) is a typical temperature-sensitive hydrogel,which has hydrophilic acylamino and hydrophobic isopropyl groups. Because of its specially reversible swelling/shrinking properties with temperature changes,it is widely used as a new kind of intelligent material. This review mainly introduces synthesis of hydrophobically modified thermo-sensitive hydrogels. Introduction of hydrophobic monomers can improve its hydrophobic properties and increase its temperature sensitivity , so it has unique application in drug delivery , material separation and biomedical materials. There are some limitations of hydrophobically modified thermo-sensitive hydrogels in theoretical research and actual applications,so we should improve the functional groups of hydrophobic monomers,and synthesize more sensitive and environment-friendly temperature-sensitive hydrogels,expanding the applications to catalysis,water treatment,biological and chemical fields.