中国医药
中國醫藥
중국의약
CHINA MEDICINE
2013年
9期
1206-1208
,共3页
盖延红%陈伟%徐丹%张美华
蓋延紅%陳偉%徐丹%張美華
개연홍%진위%서단%장미화
急性冠状动脉综合征%脑钠肽%左心室容积%左心室射血分数
急性冠狀動脈綜閤徵%腦鈉肽%左心室容積%左心室射血分數
급성관상동맥종합정%뇌납태%좌심실용적%좌심실사혈분수
Acute coronary syndrome%Brain natriuretic peptide%Volume of left ventricular%Ejection fraction of left ventricular
目的 探讨急性冠状动脉综合征(ACS)患者血清脑钠肽(BNP)水平及其与左心室功能的关系.方法 选取2008年1月至2009年1月青岛大学医学院第二附属医院住院的冠心病患者104例,其中ACS 74例[急性心肌梗死(AMI) 36例,不稳定型心绞痛(UAP)38例],稳定型心绞痛(SAP)患者30例,以同期到我院的体检健康者30名作为正常对照组.用酶联免疫吸附测定法分析血清BNP浓度,并行心脏超声心动图检查.测定所有研究对象的左心室射血分数(LVEF)、左心室收缩末期容积及舒张末期容积.结果 ACS组(AMI组和UAP组)的血清BNP浓度[(391±136) ng/L,(267±80) ng/L]均明显高于SAP组[(36±21)ng/L]和对照组[(33±14)ng/L],差异均有统计学意义(均P＜0.05),在LVEF正常的冠心病患者,ACS组的BNP水平[(277±160) ng/L]高于SAP组[(74±32) ng/L],差异有统计学意义(P＜0.05),ACS组BNP与LVEF呈负相关(r=-0.44,P＜0.01).结论 ①血清BNP浓度在ACS患者中升高.②ACS患者BNP浓度的升高除了与心脏大小和射血分数相关外,也可能与缺血损伤造成的急性期炎症反应有关.
目的 探討急性冠狀動脈綜閤徵(ACS)患者血清腦鈉肽(BNP)水平及其與左心室功能的關繫.方法 選取2008年1月至2009年1月青島大學醫學院第二附屬醫院住院的冠心病患者104例,其中ACS 74例[急性心肌梗死(AMI) 36例,不穩定型心絞痛(UAP)38例],穩定型心絞痛(SAP)患者30例,以同期到我院的體檢健康者30名作為正常對照組.用酶聯免疫吸附測定法分析血清BNP濃度,併行心髒超聲心動圖檢查.測定所有研究對象的左心室射血分數(LVEF)、左心室收縮末期容積及舒張末期容積.結果 ACS組(AMI組和UAP組)的血清BNP濃度[(391±136) ng/L,(267±80) ng/L]均明顯高于SAP組[(36±21)ng/L]和對照組[(33±14)ng/L],差異均有統計學意義(均P＜0.05),在LVEF正常的冠心病患者,ACS組的BNP水平[(277±160) ng/L]高于SAP組[(74±32) ng/L],差異有統計學意義(P＜0.05),ACS組BNP與LVEF呈負相關(r=-0.44,P＜0.01).結論 ①血清BNP濃度在ACS患者中升高.②ACS患者BNP濃度的升高除瞭與心髒大小和射血分數相關外,也可能與缺血損傷造成的急性期炎癥反應有關.
목적 탐토급성관상동맥종합정(ACS)환자혈청뇌납태(BNP)수평급기여좌심실공능적관계.방법 선취2008년1월지2009년1월청도대학의학원제이부속의원주원적관심병환자104례,기중ACS 74례[급성심기경사(AMI) 36례,불은정형심교통(UAP)38례],은정형심교통(SAP)환자30례,이동기도아원적체검건강자30명작위정상대조조.용매련면역흡부측정법분석혈청BNP농도,병행심장초성심동도검사.측정소유연구대상적좌심실사혈분수(LVEF)、좌심실수축말기용적급서장말기용적.결과 ACS조(AMI조화UAP조)적혈청BNP농도[(391±136) ng/L,(267±80) ng/L]균명현고우SAP조[(36±21)ng/L]화대조조[(33±14)ng/L],차이균유통계학의의(균P＜0.05),재LVEF정상적관심병환자,ACS조적BNP수평[(277±160) ng/L]고우SAP조[(74±32) ng/L],차이유통계학의의(P＜0.05),ACS조BNP여LVEF정부상관(r=-0.44,P＜0.01).결론 ①혈청BNP농도재ACS환자중승고.②ACS환자BNP농도적승고제료여심장대소화사혈분수상관외,야가능여결혈손상조성적급성기염증반응유관.
Objective To detect the expression of serum brain natriuretic peptide (BNP) and relation with the function of left ventricular in the patients with acute coronary syndrome.Methods Patients with acute myocardial infarction (AMI) (36 cases),unstable angina pectoris(UAP) (38 cases),stable angina pectoris(SAP) (30 cases) were selected,30 cases with normal physical examination were chosen as control group.The serum BNP concentration determined with enzyme linked immuno-asorbent assay method echocardiography was performed in all patients.The left ventricular ejection fraction,the end of the left ventricular systohc and end-diastolic volume were determined.Results The BNP serum concentration of AMI group (391 ± 136)ng/L and UAP group (267 ± 80) ng/L were significantly higher than SAP group (36 ± 21) ng/L and control group (33 ± 14) ng/L,the difference was significant (P ＜ 0.05).Normal LVEF of patients with coronary heart disease,the serum BNP concentration in ACS group(277 ± 160)ng/L was higher than SAP group(74 ± 33)ng/L.The serum BNP concentration in ACS group was negative correlated with LVEF (r =-0.44,P ＜ 0.01).Conclusions The serum BNP concentration in patients with ACS increase significantly.BNP concentration increases in patients with ACS,which is mainly caused by volume of heart the size and ejection fraction,while acute phase of the inflammatory response after ischemic contributes to increase.
