CAJ | 학술논문

【目的】评价α-硫辛酸对初诊2型糖尿病（T2DM）患者胰岛β细胞功能及氧化应激水平影响。【方法】将2013年3～9月秦皇岛市第一医院的80例初诊T2DM患者随机分为A、B两组，均行胰岛素泵强化治疗2周，A组同时静脉输注α-硫辛酸。治疗前及治疗2周后检测两组患者的血糖、血脂，采用稳态模型（HOMA）计算胰岛β细胞功能指数（HOMA-β），酶联免疫吸附法检测尿8-异前列腺素 F2α（8-isoPGE），评价氧化应激水平。【结果】治疗后，A组 HOMA-β显著高于B组（P＜0．05），8-isoPGF分泌率[F2α（8-isoPGE）/Cr]显著低于B组（P＜0．05），F2α（8-isoPGE）/Cr与餐后2 h血糖（2hPG）（r＝0．432，P＜0．01）、总胆固醇（TC）（r ＝0．315，P ＜0．01）、体质量指数（BMI）（r ＝0．256，P ＜0．05）呈正相关，与 HOMA-β（r ＝-0．217，P＜0．05）呈负相关。2hPG是尿F2α（8-isoPGE）/Cr的独立危险因素。【结论】应用α-硫辛酸可改善初诊T2DM患者胰岛β细胞功能，降低氧化应激水平。
【목적】평개α-류신산대초진2형당뇨병（T2DM）환자이도β세포공능급양화응격수평영향。【방법】장2013년3～9월진황도시제일의원적80례초진T2DM환자수궤분위A、B량조，균행이도소빙강화치료2주，A조동시정맥수주α-류신산。치료전급치료2주후검측량조환자적혈당、혈지，채용은태모형（HOMA）계산이도β세포공능지수（HOMA-β），매련면역흡부법검측뇨8-이전렬선소 F2α（8-isoPGE），평개양화응격수평。【결과】치료후，A조 HOMA-β현저고우B조（P＜0．05），8-isoPGF분비솔[F2α（8-isoPGE）/Cr]현저저우B조（P＜0．05），F2α（8-isoPGE）/Cr여찬후2 h혈당（2hPG）（r＝0．432，P＜0．01）、총담고순（TC）（r ＝0．315，P ＜0．01）、체질량지수（BMI）（r ＝0．256，P ＜0．05）정정상관，여 HOMA-β（r ＝-0．217，P＜0．05）정부상관。2hPG시뇨F2α（8-isoPGE）/Cr적독립위험인소。【결론】응용α-류신산가개선초진T2DM환자이도β세포공능，강저양화응격수평。
[Obj ective]To evaluate the effect ofα-lipoic acid on islet beta cell function and oxidative stress in patients with new diagnosed type 2 diabetes mellitus(T2DM).[Methods]Totally 80 patients with new di-agnosed T2DM in first hospital of Qinhuangdao city from March 2013 to Sept.2013 were randomly divided in-to group A and group B.All patients were given insulin pump intensification therapy for 2 weeks.Group A was simultaneously treated with intravenous infusion ofα-lipoic acid.Blood glucose and lipids of two groups were measured before and 2 weeks after treatment.Islet beta cell function index(HOMA-β)was calculated by using steady state model(HOMA).Enzyme linked immunosorbent assay was used to detect urine 8-isoprostan-es F2α(8-isoPGE).Oxidative stress was assessed.[Results]After treatment,HOMA-βin group A was higher than that in group B(P<0.05),while urine F2α(8-isoPGE)/Cr in group A was lower than that in group B(P<0.05).F2α(8-isoPGE)/Cr was positively correlated with 2h-postprandial glucose(2hPG)(r=0.432,P<0.01),total cholesterol(TC)(r=0.315,P<0.01)and body mass index(BMI)(r=0.256,P<0.05),but negatively correlated with HOMA-β(r=-0.217,P<0.05).The 2hPG was the independent risk factor of secretory rate of F2α(8-isoPGE)/Cr.[Conclusion]Theα-lipoic acid can improve islet beta cell function and re-duce oxidative stress level of patients with new diagnosed T2DM.