CAJ | 학술논문

【目的】探讨肺腺癌患者表皮生长因子受体酪氨酸激酶结构域（EGFR-TKD）突变与放射敏感性的关系。【方法】将36例肺腺癌并 EGFR-TKD突变者列为观察组，24例无突变者列为对照组。对两组患者肺部原发病灶均采用三维适形放射治疗，放疗结束后1个月复查胸部 CT评价近期疗效。【结果】全部患者均顺利完成治疗，观察组完全缓解（CR）10例，部分缓解（PR）24例，稳定2例，进展0例，近期总有效率（CR＋PR）94．4％。对照组CR 7例，PR 10例，稳定6例，进展1例，近期总有效率70．8％。两组患者近期有效率比较差异有显著性（P＜0．05）。【结论】肺腺癌 EGFR-TKD突变患者的近期放疗效果好，提示 EGFR-TKD突变是预测放射敏感性的重要指标。
【목적】탐토폐선암환자표피생장인자수체락안산격매결구역（EGFR-TKD）돌변여방사민감성적관계。【방법】장36례폐선암병 EGFR-TKD돌변자렬위관찰조，24례무돌변자렬위대조조。대량조환자폐부원발병조균채용삼유괄형방사치료，방료결속후1개월복사흉부 CT평개근기료효。【결과】전부환자균순리완성치료，관찰조완전완해（CR）10례，부분완해（PR）24례，은정2례，진전0례，근기총유효솔（CR＋PR）94．4％。대조조CR 7례，PR 10례，은정6례，진전1례，근기총유효솔70．8％。량조환자근기유효솔비교차이유현저성（P＜0．05）。【결론】폐선암 EGFR-TKD돌변환자적근기방료효과호，제시 EGFR-TKD돌변시예측방사민감성적중요지표。
[Obj ective]To explore the relationship between epidermal growth factor receptor tyrosine kinase domain (EGFR-TKD)mutation and radiosensitivity in patients with lung adenocarcinoma.[Methods]A total of 3 6 lung adeno-carcinoma patients with EGFR-TKD mutation were selected as the observation group.A total of 24 patients without EG-FR-TKD mutation were selected as the control group.Three-dimensional conformal radiotherapy was performed in prima-ry lung lesions of patients in 2 groups.Chest CT reexamination was performed 1 month after radiotherapy and used to e-valuate the short-term efficacy.[Results]All patients completed the treatment smoothly.In the observation group,1 0 patients were complete remission(CR),and 24 patients were partial remission(PR),and 2 patients were stable,and no one was developed,and the short-term total effective rate(CR+PR)was 94.4%.In the control group,7 patients were complete remission(CR),and 1 0 patients were partial remission(PR),and 6 patients were stable,and 1 patient was de-veloped,and the total short-term effective rate was 70.8%.There was significant difference in the short-term efficacy be-tween two groups(P<0.05).[Conclusion]Lung adenocarcinoma patients with EGFR-TKD mutation have better short-term efficacy.It suggests that EGFR-TKD mutation is an important indicator of predicting radiosensitivity.