赣南医学院学报
贛南醫學院學報
공남의학원학보
JOURNAL OF GANNAN MEDICAL COLLEGE
2014年
3期
360-363,380
,共5页
吴峰%蔡立雄%陈健荣%王刚
吳峰%蔡立雄%陳健榮%王剛
오봉%채립웅%진건영%왕강
加味二仙颗粒%绝经后骨质疏松症 / 治疗
加味二仙顆粒%絕經後骨質疏鬆癥 / 治療
가미이선과립%절경후골질소송증 / 치료
jiaweierxian granules%postmenopausal osteoporosis/ treatment
目的:探讨加味二仙颗粒治疗绝经后骨质疏松症的临床疗效。方法:97例符合纳入标准并完成随访的绝经后妇女骨质疏松症患者随机分为试验组与对照组,试验组口服加味二仙颗粒,对照组口服仙灵骨葆胶囊,采用VAS 评分、骨密度(BMD)、骨转换标记物:BALP、DPD/ Cr、BGP 、CTX-Ⅰ及疗效评定综合比较两组治疗前后疗效。结果:在治疗后12周实验组及对照组 VAS 评分均明显改善,实验组改善更明显,BMD 在治疗后48周才出现明显改善,但实验组与对照组比较无明显统计学差异,治疗组与对照组在治疗12周后 BALP、DPD/ Cr、BGP 、CTX-Ⅰ值出现明显下降,但实验组及对照组差别不明显,治疗72周后试验组治疗有效率85.7%,对照组87.5%,差异无统计学意义。结论:加味二仙颗粒治疗绝经后骨质疏松症的临床疗效确切,用于治疗监测时,骨转换标志物改变较骨密度改变出现更早。
目的:探討加味二仙顆粒治療絕經後骨質疏鬆癥的臨床療效。方法:97例符閤納入標準併完成隨訪的絕經後婦女骨質疏鬆癥患者隨機分為試驗組與對照組,試驗組口服加味二仙顆粒,對照組口服仙靈骨葆膠囊,採用VAS 評分、骨密度(BMD)、骨轉換標記物:BALP、DPD/ Cr、BGP 、CTX-Ⅰ及療效評定綜閤比較兩組治療前後療效。結果:在治療後12週實驗組及對照組 VAS 評分均明顯改善,實驗組改善更明顯,BMD 在治療後48週纔齣現明顯改善,但實驗組與對照組比較無明顯統計學差異,治療組與對照組在治療12週後 BALP、DPD/ Cr、BGP 、CTX-Ⅰ值齣現明顯下降,但實驗組及對照組差彆不明顯,治療72週後試驗組治療有效率85.7%,對照組87.5%,差異無統計學意義。結論:加味二仙顆粒治療絕經後骨質疏鬆癥的臨床療效確切,用于治療鑑測時,骨轉換標誌物改變較骨密度改變齣現更早。
목적:탐토가미이선과립치료절경후골질소송증적림상료효。방법:97례부합납입표준병완성수방적절경후부녀골질소송증환자수궤분위시험조여대조조,시험조구복가미이선과립,대조조구복선령골보효낭,채용VAS 평분、골밀도(BMD)、골전환표기물:BALP、DPD/ Cr、BGP 、CTX-Ⅰ급료효평정종합비교량조치료전후료효。결과:재치료후12주실험조급대조조 VAS 평분균명현개선,실험조개선경명현,BMD 재치료후48주재출현명현개선,단실험조여대조조비교무명현통계학차이,치료조여대조조재치료12주후 BALP、DPD/ Cr、BGP 、CTX-Ⅰ치출현명현하강,단실험조급대조조차별불명현,치료72주후시험조치료유효솔85.7%,대조조87.5%,차이무통계학의의。결론:가미이선과립치료절경후골질소송증적림상료효학절,용우치료감측시,골전환표지물개변교골밀도개변출현경조。
Objectiye:To investigate the clinical efficacy of jiaweierxian granules treatment on postmenopausal women with osteoporosis. Methods:From January,2011 to October,2012,ninety-seven postmenopausal women with osteoporosis were enrolled in a prospective study and assigned to one of two groups. The first group received an treatment with jiaweierxian granules while the second group as the control group prescript for use of Xianlinggubao capsules. All patients were pro-spectively followed,and clinical outcomes were evaluated with Visual Analog Scale,BMD,Bone turnover markers of BALP、DPD/ Cr、BGP 、CTX-Ⅰ,comprehensive evaluation of efficacy for osteoporosis. Results:Visual Analog Scale were significantly improved in two groups after treatment for 8 weeks,the improvement were more evident in the patients in treatment of jiaweierxian granules than the control group. BMD was significantly improved only after 48 weeks treatment in two groups. However,significant difference appeared in Bone turnover markers of BALP、DPD/ Cr、BGP 、CTX-Ⅰ at 12 weeks follow-up in two groups,but there was no difference between two groups in BMD and Bone turnover markers of BALP、DPD/ Cr、BGP 、CTX-Ⅰ. At final follow-up(72weeks)the rate important improvement used comprehensive evalu-ation of efficacy for osteoporosis were 85. 7% and 87. 5% respectively in two groups and had no difference statistically. Conclusion:Jiaweierxian granules treatment on postmenopausal women with osteoporosis is effective,in monitoring the ef-ficacy of treatment on postmenopausal women with osteoporosis,the changes of bone turnover markers were earlier than that of BMD.