CAJ | 학술논문

目的：探讨半胱氨酸天门冬氨酸特异的蛋白酶9（Caspase-9）在乳腺浸润性导管癌组织中的表达及其与临床病理因素的关系。方法：采用免疫组织化学 SP 方法研究38例乳腺浸润性导管癌（breast infiltrating ductal carci-noma，IDC）、32例乳腺纤维腺瘤及其肿物旁的正常乳腺组织中 Caspase-9的表达水平，观察评估 Caspase-9的阳性表达与患者年龄、肿瘤大小、淋巴结转移等临床病理因素的相关性，并探讨与乳腺浸润性导管癌的临床分期、组织学分级的关系。结果：乳腺浸润性导管癌、乳腺纤维腺瘤组织中的 Caspase-9的阳性表达均低于正常乳腺组织（<0.05），且乳腺浸润性导管癌明显低度表达（<0.01）。其表达水平与患者年龄、肿瘤大小、淋巴结转移等不相关（>0.05），与临床分期、组织学分级明显负相关（<0.01）。结论：Caspase-9低表达与乳腺浸润性导管癌的恶化显著相关，该指标有助于乳腺浸润性导管癌的预后判断，其可能成为潜在乳腺肿瘤标志物，并成为治疗的靶点。
목적：탐토반광안산천문동안산특이적단백매9（Caspase-9）재유선침윤성도관암조직중적표체급기여림상병리인소적관계。방법：채용면역조직화학 SP 방법연구38례유선침윤성도관암（breast infiltrating ductal carci-noma，IDC）、32례유선섬유선류급기종물방적정상유선조직중 Caspase-9적표체수평，관찰평고 Caspase-9적양성표체여환자년령、종류대소、림파결전이등림상병리인소적상관성，병탐토여유선침윤성도관암적림상분기、조직학분급적관계。결과：유선침윤성도관암、유선섬유선류조직중적 Caspase-9적양성표체균저우정상유선조직（<0.05），차유선침윤성도관암명현저도표체（<0.01）。기표체수평여환자년령、종류대소、림파결전이등불상관（>0.05），여림상분기、조직학분급명현부상관（<0.01）。결론：Caspase-9저표체여유선침윤성도관암적악화현저상관，해지표유조우유선침윤성도관암적예후판단，기가능성위잠재유선종류표지물，병성위치료적파점。
Objectiye:To investigate the expression of Caspase-9 protein in breast infiltrating ductal carcinoma(IDC)and its clinical significance. Methods:The expression of Caspase-9 was detected by streptavidin-perosidase(SP)with tissues of thirty-eight cases of IDC and thirty-two cases of fibroadenoma,including normal tissues adjacent to tumor. Positive ex-pression of Caspase-9 relation with clinicopathological factors such as age,tumor size,lymph node metastasis were ob-served. Furthermore,clinical stage and histopathologic grade were explored in IDC. Results:The expression of Caspase-9 in IDC tissues and fibroadenoma tissues were lower than that in adjacent normal tissues( < 0. 05). Meanwhile,the IDC tissues was significantly down-regulated( < 0. 01). The expression of Caspase-9 was independent of clinicopathological parameters,such as age,tumor size,lymph node metastasis( > 0. 05). However,It had obvious negative correlation with clinical stage and histopathologic grade( < 0. 01). Conclusion:The lower expression of Caspase-9 closely correlates to the progress of breast infiltrating ductal carcinoma. The index greatly contributes to judgment of prognosis of breast infiltra-ting ductal carcinoma. Indicating that Caspase-9 might be used as a tumor biomarker and a potential therapeutic target for inhibiting the invasive of breast infiltrating ductal carcinoma.