CAJ | 학술논문

目的：研究佛甲草醇提物对大鼠佐剂性关节炎的治疗作用并探讨其对氧自由基的影响。方法：采用弗氏完全佐剂免疫诱导大鼠佐剂性关节炎动物模型；观察不同浓度佛甲草提取物对佐剂性关节炎（AA）大鼠的慢性足肿胀度、血清中一氧化氮（NO）含量及谷胱甘肽过氧化物酶（GSH-PX）活性的影响。结果：与模型组相比，高、低剂量的佛甲草醇提物均能抑制大鼠慢性足肿胀，降低大鼠的血清 NO 水平，并使 GSH-Px 的含量增加。结论：佛甲草醇提物对大鼠佐剂性关节炎有治疗作用，其作用可能与其恢复抗氧化物酶活性，提高自由基的清除能力有关。
목적：연구불갑초순제물대대서좌제성관절염적치료작용병탐토기대양자유기적영향。방법：채용불씨완전좌제면역유도대서좌제성관절염동물모형；관찰불동농도불갑초제취물대좌제성관절염（AA）대서적만성족종창도、혈청중일양화담（NO）함량급곡광감태과양화물매（GSH-PX）활성적영향。결과：여모형조상비，고、저제량적불갑초순제물균능억제대서만성족종창，강저대서적혈청 NO 수평，병사 GSH-Px 적함량증가。결론：불갑초순제물대대서좌제성관절염유치료작용，기작용가능여기회복항양화물매활성，제고자유기적청제능력유관。
Objectiye:To observe the therapeutic effect of Sedum lineare Thunb(SLT)on adjuvant arthritis and its effects on antioxidation in mice. Method:By establishing rheumatoid arthritis rats model with injecting Freund complete adju-vant,observe the effect of the high and low dosage of SLT to the chronic paw swelling,nitric oxide(NO)content and glu-tathione peroxidase(GSH-Px)activity in serum. Result:Both SLT groups could reduce the swelling of the model rats, change the level of serum NO,which were lower than the model group,whereas the SLT groups increased the activity of serum GSH-Px. Conclusion:SLT had therapeutic action to rheumatoid arthritis rats,and the mechanism probably was that SLT could strengthen the activity of antioxidase,and scavenge oxygen-free radicals.