CAJ | 학술논문

流感是由流感病毒引起的呼吸道疾病，它通过呼吸道传播，曾多次引起全球大流行，造成了人力和物力的重大损失。流感病毒变异率高，传播速度快，控制其危害仍是医学界的一项艰巨的任务。目前治疗和预防流感的方法是药物治疗和接种疫苗，治疗药物多为口服药，疫苗接种多为肌肉注射。流感病毒主要吸附纤毛上皮细胞以及含α-2，6半乳糖苷唾液酸丰富的气管和支气管上皮细胞，其一旦定植于呼吸道黏膜表面，经吞饮作用，黏附和穿入柱状上皮细胞，并在细胞内进行复制，可短期内导致大量呼吸道上皮细胞受染，受染细胞发生坏死、脱落及局部炎症反应。本文主要综述了流感的局部治疗和预防方面的研究。
류감시유류감병독인기적호흡도질병，타통과호흡도전파，증다차인기전구대류행，조성료인력화물력적중대손실。류감병독변이솔고，전파속도쾌，공제기위해잉시의학계적일항간거적임무。목전치료화예방류감적방법시약물치료화접충역묘，치료약물다위구복약，역묘접충다위기육주사。류감병독주요흡부섬모상피세포이급함α-2，6반유당감타액산봉부적기관화지기관상피세포，기일단정식우호흡도점막표면，경탄음작용，점부화천입주상상피세포，병재세포내진행복제，가단기내도치대량호흡도상피세포수염，수염세포발생배사、탈락급국부염증반응。본문주요종술료류감적국부치료화예방방면적연구。
Influenza is a respiratory disease caused by influenza viruses , which spreads through the respiratory tract .It has caused global pandemic many times and posed a great losses of manpower and material resources .Due to the high muta-tion rate and fast transmission, it is still a arduous task to control the influenza's damage.Nowadays, methods for the treat-ment and prevention of influenza are drugs and vaccination .Most drugs are oral and vaccines are most through intramuscu-lar injection.The influenza virus is mainly adsorbed ciliated epithelium cells and the epithelial cells of tracheal and bron -chial, which were rich in α-2,6 x-gal sialic acid.The influenza virus once occupied in the surface of respiratory tract mucous membrane .It adhered and wore into the columnar epithelial cells through the pinocytosis and replicated in the cells.It resulted in a large number of airway epithelial cells being affected and the infected cells were necrosis and ecclasis and led to local inflammatory response .This paper mainly summarizes the research about local treatment and prevention of influenza.