CAJ | 학술논문

目的：探讨血糖控制不佳的2型糖尿病严格治疗前后右心室功能的变化。方法随机连续入组65例2型糖尿病患者，检测控制血糖前后患者的空腹血糖、糖化血红蛋白、血脂等指标；应用超声诊断仪测量三尖瓣环收缩位移、收缩期峰值速度、右室游离壁基底段应变和中间段应变。结果控制血糖后与控制前比较，右室基底段和中间段应变均明显改善（29．7±6．4 vs．26．1±6．7，30．3±6．3 vs．26．5±5．5， P均＜0．05）；其改善幅度与糖化血红蛋白的降低程度呈正相关（相关系数为0．369和0．345，P均＜0．01），与空腹血糖降低幅度呈正相关（相关系数为0．378和0．372，P均＜0．01），与血脂和血压无相关性（P均＞0．05）。结论积极药物治疗能减轻糖尿病患者血糖控制不佳对右室长轴收缩功能的损伤。
목적：탐토혈당공제불가적2형당뇨병엄격치료전후우심실공능적변화。방법수궤련속입조65례2형당뇨병환자，검측공제혈당전후환자적공복혈당、당화혈홍단백、혈지등지표；응용초성진단의측량삼첨판배수축위이、수축기봉치속도、우실유리벽기저단응변화중간단응변。결과공제혈당후여공제전비교，우실기저단화중간단응변균명현개선（29．7±6．4 vs．26．1±6．7，30．3±6．3 vs．26．5±5．5， P균＜0．05）；기개선폭도여당화혈홍단백적강저정도정정상관（상관계수위0．369화0．345，P균＜0．01），여공복혈당강저폭도정정상관（상관계수위0．378화0．372，P균＜0．01），여혈지화혈압무상관성（P균＞0．05）。결론적겁약물치료능감경당뇨병환자혈당공제불가대우실장축수축공능적손상。
Objective To explore the changes of right ventricular function in patients with poor controlled diabetes before and after glycemic regulation was achieved .Methods Sixty-five consecutive type 2 diabetes patients were enrolled ran-domly.Levels of fasting plasma glucose , glycosylated hemoglobin , and lipid parameters were measured before the onset of the treatment and after glycemic regulation was achieved .The tricuspid annulus systolic displacement , the tricuspid annular peak systolic velocity , the strain at basal segments and at middle segments of right ventricular free wall were acquired by echocardiography .Results A significant improvements in the strain at basal segments and at middle segments of right ven -tricle (29.7 ±6.4 vs.26.1 ±6.7, 30.3 ±6.3 vs.26.5 ±5.5, P<0.05, both) were observed, after improving glycemic control.The improvement in the strain levels was positively correlated with the decrease in glycosylated hemoglobin ( r=0.369 and r=0.345, respectively, P<0.01, both), and the decrease in fasting plasma glucose ( r=0.378 and r=0.372, respectively, P<0.01, both).There was no correlation between the glycemic regulation and lipid parameters and blood pressures (P>0.05, all).Conclusion The damage of poor glycemic control to the right ventricular longitudinal sys -tolic function in diabetes could be relieved after active medications .