CAJ | 학술논문

【目的】探讨胸腔镜心包开窗术联合沙培林腔内用药治疗恶性心包积液的临床疗效。【方法】选择2009年1月至2013年1月本院收治的38例恶性心包积液患者，随机分为两组：对照组采用常规保守治疗，观察组采用胸腔镜心包开窗术治疗，术中心包灌注沙培林。对两组患者的近期疗效、病情进展时间和中位生存时间、手术前后Karnofsky评分进行比较。【结果】观察组的近期治疗有效率（94．7％）高于对照组（55．6％），差异有统计学意义（P＜0．05）。观察组手术后病情进展时间和中位生存时间长于对照组，差异有统计学意义（P＜0．05）。观察组手术后的Karnofsky评分高于对照组，差异有统计学意义（P ＜0．05）。【结论】胸腔镜心包开窗术联合沙培林腔内用药治疗恶性心包积液疗效好，可明显改善患者的临床症状，延长生存时间，提高生活质量，值得进一步推广应用。
【목적】탐토흉강경심포개창술연합사배림강내용약치료악성심포적액적림상료효。【방법】선택2009년1월지2013년1월본원수치적38례악성심포적액환자，수궤분위량조：대조조채용상규보수치료，관찰조채용흉강경심포개창술치료，술중심포관주사배림。대량조환자적근기료효、병정진전시간화중위생존시간、수술전후Karnofsky평분진행비교。【결과】관찰조적근기치료유효솔（94．7％）고우대조조（55．6％），차이유통계학의의（P＜0．05）。관찰조수술후병정진전시간화중위생존시간장우대조조，차이유통계학의의（P＜0．05）。관찰조수술후적Karnofsky평분고우대조조，차이유통계학의의（P ＜0．05）。【결론】흉강경심포개창술연합사배림강내용약치료악성심포적액료효호，가명현개선환자적림상증상，연장생존시간，제고생활질량，치득진일보추엄응용。
[Obj ective]To explore clinical efficacy of pericardial fenestration by thoracoscopy combined with intracavity sapylin for the treatment of malignant pericardial effusion.[Methods]Totally 38 patients with malignant pericardial effusion in our hospital from Jan.2009 to Jan.2013 were randomly divided into two groups.The control group was given conventional conservative treatment,while the observation group was given pericardial fenestration by thoracoscopy and perfused with Sapylin during the operation.The short-term efficacy,disease progression time,median survival time and Karnofsky score of two groups before and after treatment were compared.[Results]The short-term effective rate of observation group(94.7%)was higher than that of control group(55.6%),and there was significant difference(P<0.05).The disease progression time and mean survival time in observation group after operation were longer than those in control group,and there was significant difference(P<0.05).Karnofsky score of observation group after operation was higher than that of control group,and there was significant difference(P<0.05).[Conclusion]Pericardial fenestra-tion by thoracoscopy combined with intracavity Sapylin for the treatment of malignant pericardial effusion has good efficacy,and can obviously improve clinical symptoms,prolong the survival time and increase quality of life of patients.Therefore,it is worthy of further clinical promotion.