CAJ | 학술논문

【目的】探讨半乳糖凝集素-3（galectin-3，GAL-3）在原发性干燥综合征（primary Sjgren＇s syndrome， pSS）及其继发间质性肺病（interstitial lung disease，ILD）发病机制中的作用。【方法】比较73例合并及不合并ILD的pSS患者的临床指标，应用ELISA方法检测73例pSS患者及20例正常对照者血清GAL-3水平。【结果】pSS患者血清 GAL-3水平明显高于正常对照组，且差异有显著性[（795．1±79．3）pg/mL ＆（458．0±97．4） pg/mL，P＜0．05）]，而 pSS-ILD患者 Gal-3水平显著高于单纯 pSS患者[（1047±110．7）pg/mL ＆（628．6±72．62）pg/mL，P＜0．01）]。此外，pSS-ILD患者免疫球蛋白 IgG、补体C3、纤维蛋白原（FiB）、C反应蛋白（CRP）及血沉水平明显高于单纯 pSS患者且差异均有显著性（P＜0．05或P＜0．01），血清白蛋白（ALB）则明显低于单纯 pSS患者（P＜0．01）。而且 pSS患者 Gal-3水平与CRP、IgG及 FiB呈正相关关系（r＝0．487，P ＜0．001，r＝0．334，P＝0．004，r＝0．482，P＜0．001）。【结论】半乳糖凝集素-3可能参与pSS的免疫炎症损伤及肺间质纤维化的发生发展。
【목적】탐토반유당응집소-3（galectin-3，GAL-3）재원발성간조종합정（primary Sjgren＇s syndrome， pSS）급기계발간질성폐병（interstitial lung disease，ILD）발병궤제중적작용。【방법】비교73례합병급불합병ILD적pSS환자적림상지표，응용ELISA방법검측73례pSS환자급20례정상대조자혈청GAL-3수평。【결과】pSS환자혈청 GAL-3수평명현고우정상대조조，차차이유현저성[（795．1±79．3）pg/mL ＆（458．0±97．4） pg/mL，P＜0．05）]，이 pSS-ILD환자 Gal-3수평현저고우단순 pSS환자[（1047±110．7）pg/mL ＆（628．6±72．62）pg/mL，P＜0．01）]。차외，pSS-ILD환자면역구단백 IgG、보체C3、섬유단백원（FiB）、C반응단백（CRP）급혈침수평명현고우단순 pSS환자차차이균유현저성（P＜0．05혹P＜0．01），혈청백단백（ALB）칙명현저우단순 pSS환자（P＜0．01）。이차 pSS환자 Gal-3수평여CRP、IgG급 FiB정정상관관계（r＝0．487，P ＜0．001，r＝0．334，P＝0．004，r＝0．482，P＜0．001）。【결론】반유당응집소-3가능삼여pSS적면역염증손상급폐간질섬유화적발생발전。
[Obj ective]To explore the role of galectin-3 (GAL-3 )in pathogenesis of primary Sjgren's syn-drome(pSS)patients with interstitial lung disease(ILD).[Methods]Clinical indexes of 73 pSS patients with and without ILD were compared.Enzyme linked immunosorbent assay(ELISA)was used to detect serum levels of GAL-3 in 73 pSS patients and 20 normal controls.[Results]Serum GAL-3 levels in pSS patients were obviously higher than those in normal controls,and there was significant difference(795.1±79.3pg/mL vs.458.0±97.4 pg/mL,P<0.05).Serum GAL-3 levels in pSS-ILD patients were markedly higher than those in simple pSS pa-tients(1047±110.7 pg/ml vs.628.6±72.62 pg/ml,P<0.01).Furthermore,the levels of IgG,C3,fibrinogen (FiB),acute phase reactive protein(CRP)and blood sedimentation in pSS-ILD patients were obviously higher than those in simple pSS patients,and there was significant difference(P<0.05 or P<0.01).Serum albumin(ALB) levels in pSS-ILD patients were obviously lower than those in simple pSS patients(P<0.01).Serum GAL-3 lev-els in pSS patients were positively correlated with CRP,IgG and FiB(r=0.487,P <0.001,r= 0.334,P =0.004,r=0.482,P<0.001).[Conclusion]GAL-3 may participate in immune inflammatory injury of pSS and the occurrence and development of ILD.