医学临床研究
醫學臨床研究
의학림상연구
JOURNAL OF CLINICAL RESEARCH
2014年
6期
1047-1048,1049
,共3页
石成良%沈永奇%曾自力%周媛媛
石成良%瀋永奇%曾自力%週媛媛
석성량%침영기%증자력%주원원
肝肿瘤/放射疗法%成像,三维
肝腫瘤/放射療法%成像,三維
간종류/방사요법%성상,삼유
Liver Neoplasms/RT%Imaging,Three-Dimensional
【目的】探讨三维适形(3DCRT)和静态调强(sIMRT)在肝癌放射性治疗中的剂量学差异。【方法】选择原发性肝右叶癌患者38例,所有患者均进行3DCRT和 sIMRT放疗,剂量均为50 Gy,分25次照射。比较不同放疗的靶区及危险器官剂量学参数、加速器跳数(MU)和有效治疗时间参数等。【结果】sIMRT放疗的Dmax、Dmin、V95%靶区剂量学分别为(52.9±0.3)Gy、(49.0±0.2)Gy、(99.5±0.2)%,与3DCRT (53.1±0.4)Gy、(46.2±0.6)Gy、(97.4±1.5)%比较剂量明显减少,比较有统计学意义(P<0.05);sIMRT的肝平均剂量(20.1±4.3)Gy与3DCRT的(21.3±3.4)Gy比较无显著性差异(P >0.05);3DCRT的 MU为(403±97)与 sIMRT(391±82)比较无显著性差异(P>0.05);3DCRT有效治疗时间为(2.0±0.1)min少于 sIMRT(4.9±0.6)min,差异有显著性(P<0.05)。【结论】sIMRT与3DCRT比较,可显著性提高疗效,改善肝癌靶区的剂量覆盖,因此 sIMRT放疗技术是治疗肝癌的更有效手段。
【目的】探討三維適形(3DCRT)和靜態調彊(sIMRT)在肝癌放射性治療中的劑量學差異。【方法】選擇原髮性肝右葉癌患者38例,所有患者均進行3DCRT和 sIMRT放療,劑量均為50 Gy,分25次照射。比較不同放療的靶區及危險器官劑量學參數、加速器跳數(MU)和有效治療時間參數等。【結果】sIMRT放療的Dmax、Dmin、V95%靶區劑量學分彆為(52.9±0.3)Gy、(49.0±0.2)Gy、(99.5±0.2)%,與3DCRT (53.1±0.4)Gy、(46.2±0.6)Gy、(97.4±1.5)%比較劑量明顯減少,比較有統計學意義(P<0.05);sIMRT的肝平均劑量(20.1±4.3)Gy與3DCRT的(21.3±3.4)Gy比較無顯著性差異(P >0.05);3DCRT的 MU為(403±97)與 sIMRT(391±82)比較無顯著性差異(P>0.05);3DCRT有效治療時間為(2.0±0.1)min少于 sIMRT(4.9±0.6)min,差異有顯著性(P<0.05)。【結論】sIMRT與3DCRT比較,可顯著性提高療效,改善肝癌靶區的劑量覆蓋,因此 sIMRT放療技術是治療肝癌的更有效手段。
【목적】탐토삼유괄형(3DCRT)화정태조강(sIMRT)재간암방사성치료중적제량학차이。【방법】선택원발성간우협암환자38례,소유환자균진행3DCRT화 sIMRT방료,제량균위50 Gy,분25차조사。비교불동방료적파구급위험기관제량학삼수、가속기도수(MU)화유효치료시간삼수등。【결과】sIMRT방료적Dmax、Dmin、V95%파구제량학분별위(52.9±0.3)Gy、(49.0±0.2)Gy、(99.5±0.2)%,여3DCRT (53.1±0.4)Gy、(46.2±0.6)Gy、(97.4±1.5)%비교제량명현감소,비교유통계학의의(P<0.05);sIMRT적간평균제량(20.1±4.3)Gy여3DCRT적(21.3±3.4)Gy비교무현저성차이(P >0.05);3DCRT적 MU위(403±97)여 sIMRT(391±82)비교무현저성차이(P>0.05);3DCRT유효치료시간위(2.0±0.1)min소우 sIMRT(4.9±0.6)min,차이유현저성(P<0.05)。【결론】sIMRT여3DCRT비교,가현저성제고료효,개선간암파구적제량복개,인차 sIMRT방료기술시치료간암적경유효수단。
[Objective]To explore the difference of dosiology of three-dimensional conformal(3DCRT)and static intensity-modulated radiology(sIMRT)in radiation therapy for liver cancer.[Methods]Totally 38 pa-tients with primary right lobe cancer of liver were chosen.All patients received 3DCRT and sIMRT.The dose was 50Gy for 25 fractions of radiation.The dosiology parameters of different radiotherapy target area and dan-gerous organ,accelerator hops(MU)and effective treatment time parameters were compared.[Results]The Dmax/Gy,Dmin/Gy and V95% target region dosiology in sIMRT were (52.9±0.3),(49.0±0.2)and (99.5±0.2)respectively which were lower than those in 3DCRT[(53.1±0.4),(46.2±0.6)and (97.4± 1.5),respectively],and there were significant differences(P<0.05).There was no significant difference in mean liver dose between sIMRT and sDCRT[(20.1± 4.3)Gy vs.(21.3±3.4)Gy](P>0.05).There was no significant difference in MU between 3DCRT and sIMRT[(403 ± 97)vs.(391±82)](P>0.05).The effective treatment time of 3DCRT was (2.0±0.1)min which was less than that in sIMRT[(4.9± 0.6)min] (P<0.05).[Conclusion]Both sIMRT and 3DCRT can markedly increase the curative effect and improve liv-er target dose coverage.Therefore,sIMRT technology is more effective means of treating liver cancer.