CAJ | 학술논문

【目的】研究 p21基因 rs1059234位点多态性与东北地区汉族女性子宫内膜癌之间的相关性。【方法】通过测序及PCR-RFLP方法，对263例子宫内膜癌患者（观察组）及315例健康人群（对照组）的外周血DNA的 p21基因 rs1059234位点进行基因型分型，并分析分型与子宫内膜癌之间的相关性。【结果】观察组中 rs1059234位点C等位基因频率较对照组明显升高（P ＝0．039）。rs1059234位点 CC基因型频率在观察组中与对照组相比呈明显升高趋势（0．335vs 0．219，P＝0．045），CC基因型增加子宫内膜癌的风险（OR＝1．589，95％ CI：1．010～2．502），但是经回归分析校正后，CC 基因型并不增加子宫内膜癌的风险（OR＝1．623，95％ CI：0．720～3．659，P＝0．243）。【结论】在东北地区汉族女性中，p21基因 rs1059234位点的多态性与子宫内膜癌的发生风险无明显关联。
【목적】연구 p21기인 rs1059234위점다태성여동북지구한족녀성자궁내막암지간적상관성。【방법】통과측서급PCR-RFLP방법，대263례자궁내막암환자（관찰조）급315례건강인군（대조조）적외주혈DNA적 p21기인 rs1059234위점진행기인형분형，병분석분형여자궁내막암지간적상관성。【결과】관찰조중 rs1059234위점C등위기인빈솔교대조조명현승고（P ＝0．039）。rs1059234위점 CC기인형빈솔재관찰조중여대조조상비정명현승고추세（0．335vs 0．219，P＝0．045），CC기인형증가자궁내막암적풍험（OR＝1．589，95％ CI：1．010～2．502），단시경회귀분석교정후，CC 기인형병불증가자궁내막암적풍험（OR＝1．623，95％ CI：0．720～3．659，P＝0．243）。【결론】재동북지구한족녀성중，p21기인 rs1059234위점적다태성여자궁내막암적발생풍험무명현관련。
[Objective]To explore the correlation between p21 gene rs1059234 polymorphisms and endome-trial cancer in Han women from northeast China.[Methods]The sequencing and PCR-restriction fragment length polymorphism(PCR-RFLP)were used for the genotyping of p21 gene rs1059234 in peripheral blood DNA of 263 patients with endometrial cancer(observation group)and 315 healthy subjects(control group). The correlation between the genotypes and endometrial cancer was analyzed.[Results]Compared with control group,the C allele frequency of rs1059234 in observation group was increased obviously(P=0.039),and the CC genotype frequency of rs1059234 in observation group had obvious increasing trend(0.335 vs.0.219,P=0.045).The CC genotype could increase the risk of endometrial cancer(OR=1.589,95%CI:1.010~2.502). After correction with regression analysis,the CC genotype didn't increase the risk of endometrial cancer(OR=1.623,95% CI:0.720~3.659,P =0.243).[Conclusion]Among Han women from northeast China,the rs1059234 polymorphism of p21 gene is not associated with the risk of endometrial cancer.