CAJ | 학술논문

目的：观察右旋美托咪定对恩氟烷催眠、镇痛作用的影响。方法将昆明种小鼠随机分为恩氟烷组（ En组）、右旋美托咪定组（ Dex组）、恩氟烷与右旋美托咪定合用组（ En＋Dex组）。利用翻正反射实验，记录各组小鼠的入睡率；利用甩尾实验，测定各组小鼠用药前后的甩尾潜伏期（ tail-flick latency，TFL）。结果在翻正反射实验中，En＋Dex组小鼠的入睡率明显高于En组和Dex组（P＜0．05）。在甩尾实验中，与基础痛阈相比，En＋Dex组小鼠给药后20～40 min甩尾潜伏期明显增加（P＜0．01）；与En组相比，En＋Dex组小鼠给药后30～40 min甩尾潜伏期明显延长（P＜0．01，P＜0．05）。结论右旋美托咪定能增强恩氟烷的催眠、镇痛作用。
목적：관찰우선미탁미정대은불완최면、진통작용적영향。방법장곤명충소서수궤분위은불완조（ En조）、우선미탁미정조（ Dex조）、은불완여우선미탁미정합용조（ En＋Dex조）。이용번정반사실험，기록각조소서적입수솔；이용솔미실험，측정각조소서용약전후적솔미잠복기（ tail-flick latency，TFL）。결과재번정반사실험중，En＋Dex조소서적입수솔명현고우En조화Dex조（P＜0．05）。재솔미실험중，여기출통역상비，En＋Dex조소서급약후20～40 min솔미잠복기명현증가（P＜0．01）；여En조상비，En＋Dex조소서급약후30～40 min솔미잠복기명현연장（P＜0．01，P＜0．05）。결론우선미탁미정능증강은불완적최면、진통작용。
Objective To investigate the possibility of better hypnotic and analgesic effects after combined use of dexmedetomidine and enflurane .Methods Mice were randomly divided into various groups according to their different treatment of enflurane (En group) or dexmedetomidine (Dex group) alone or both (En+Dex group).The sleeping rates of each group were recorded using righting reflex test .The tail-flick latencies of each group before and after treatment were determined by tail -flick test.Results In the righting reflex test , the En +Dex group presented a higher sleeping rate than both the En and Dex groups (P<0.05).In the tail-flick test, compared with the basal line, the tail-flick latency of the En +Dex group was remarkably extended 20 to 40 min after treatment (P<0.01).Compared with the En group, the tail-flick latency of the En +Dex group was obviously extended 30 to 40 min after administration ( P<0.01 and P<0.05).Conclusion The hypnotic and analgesic effects of enflurane can be enhanced after combined used with dexmedetomidine .