CAJ | 학술논문

目的：探讨 AFP 和 HCCR-1联合检测在诊断小肝癌中的作用。方法：检测肝癌患者体内 AFP 和 HCCR-1表达水平。结果：1258例肝癌患者血清中 AFP 和 HCCR-1的检测结果：AFP 检测阳性率是576(46%),HCCR-1检测的阳性率是646(51.3%)。当 AFP 和 HC-CR-1联合检测时阳性率提高到74.1%。 AFP 和 HCCR-1分别检测小肝癌(直径小于2厘米)的阳性率是40.1%和23.4%,二者联合检测时阳性率上升为56.9%。结论：实验结果表明 HCCR-1可以作为检测肝癌的有用标志物,当 AFP 和 HCCR-1结合在一起检测,能提高小肝癌的阳性率。
목적：탐토 AFP 화 HCCR-1연합검측재진단소간암중적작용。방법：검측간암환자체내 AFP 화 HCCR-1표체수평。결과：1258례간암환자혈청중 AFP 화 HCCR-1적검측결과：AFP 검측양성솔시576(46%),HCCR-1검측적양성솔시646(51.3%)。당 AFP 화 HC-CR-1연합검측시양성솔제고도74.1%。 AFP 화 HCCR-1분별검측소간암(직경소우2전미)적양성솔시40.1%화23.4%,이자연합검측시양성솔상승위56.9%。결론：실험결과표명 HCCR-1가이작위검측간암적유용표지물,당 AFP 화 HCCR-1결합재일기검측,능제고소간암적양성솔。
Objective:To discuss effects of combined detection of AFP and HCCR-1 in diagnosis of small hepatocellular carci-noma. Methods:The levels of AFP and HCCR-1 in the patients with liver cancer were detected. Results: Of the 1258 cases of liver cancer patients, 576 (46% ) and 646 (51. 3% ) cases were positive for AFP and HCCR-1, respectively. In the combined detection of AFP and HCCR-1, the positive rate for liver cancer increased up to 74. 1% . The positive rate for small hepatocellular carcinoma (di-ameter <2 cm) increased to 56. 9% in the combined detection of AFP and HCCR-1, although those were only 40. 1% and 23. 4% of AFP ad HCCR-1, respectively. Conclusions: It suggests that the HCCR-1 is a useful biomarker for liver cancer. The positive rate of small hepatocellular carcinoma could be significantly improved in the combined detection of HCCR-1 and AFP.