CAJ | 학술논문

目的：探讨检测同型半胱氨酸对诊断和治疗妊娠期糖尿病的应用价值，期望为临床治疗提供参考。方法随机选取我院妇产科中被诊断为妊娠期糖尿病的患者80例，记为观察组，并根据血糖控制情况分为A1、A2两亚组，其中A1亚组48例、A2亚组32例；随机选取同期妊娠妇女50例，记为对照组。分别检测两组受试者的血清同型半胱氨酸浓度，研究其浓度差别，同时追踪受试者的妊娠结局，并进行相关性分析。结果 A2亚组患者的血清同型半胱氨酸水平、不良妊娠发生率均显著高于A1亚组及对照组（P＜0．05）；A1亚组患者血清同型半胱氨酸水平、不良妊娠发生率与对照组之间无显著差别（P＞0．05）。结论血清同型半胱氨酸水平可能与妊娠期糖尿病的严重程度及不良妊娠结局有关，因此临床上可以通过检测血清同型半胱氨酸水平来预知妊娠期糖尿病的发生发展，并及时采取合理的治疗措施来降低不良妊娠发生率，从而提高妊娠妇女及新生儿的生命质量。
목적：탐토검측동형반광안산대진단화치료임신기당뇨병적응용개치，기망위림상치료제공삼고。방법수궤선취아원부산과중피진단위임신기당뇨병적환자80례，기위관찰조，병근거혈당공제정황분위A1、A2량아조，기중A1아조48례、A2아조32례；수궤선취동기임신부녀50례，기위대조조。분별검측량조수시자적혈청동형반광안산농도，연구기농도차별，동시추종수시자적임신결국，병진행상관성분석。결과 A2아조환자적혈청동형반광안산수평、불량임신발생솔균현저고우A1아조급대조조（P＜0．05）；A1아조환자혈청동형반광안산수평、불량임신발생솔여대조조지간무현저차별（P＞0．05）。결론혈청동형반광안산수평가능여임신기당뇨병적엄중정도급불량임신결국유관，인차림상상가이통과검측혈청동형반광안산수평래예지임신기당뇨병적발생발전，병급시채취합리적치료조시래강저불량임신발생솔，종이제고임신부녀급신생인적생명질량。
Objective To investigate the application value of detect serum homocysteine in the diagnosis and treatment of gestational diabetes , expect to provide reference for clinical treatment .Methods Randomly chose 80 cases of patients those who were diagnosed as gestational diabetes , they were recorded in the observation group, and then they were divided into A 1, A2 subgroups according to glycolic control condition , 48 cases in A1group, 32 cases in A2 group.Another 50 cases of pregnant women at the same period were selected as control group.Serum homocysteine concentrations in both groups were measured and studied , meanwhile tracked the pregnancy outcomes and made correlation analysis .Results The serum homocysteine level and the incidence of adverse pregnancy of A2 subgroup were significantly higher than the control group and subgroup A 1 (P<0 05). The differences of serum homocysteine level and incidence of adverse pregnancy between A 1 subgroup and control group were no statistically significant (P>0.05).Conclusions Serum homocysteine levels may be associated with the severity of gestational diabetes and adverse pregnancy outcomes , therefore serum homocysteine levels can predict the development of gestational diabetes in clinical , promptly and reasonable treatment measures can reduce the incidence of adverse pregnancy , so as to improving the quality of life in pregnant women and newborns .