齐齐哈尔医学院学报
齊齊哈爾醫學院學報
제제합이의학원학보
JOURNAL OF QIQIHAR MEDICAL COLLEGE
2014年
16期
2374-2376
,共3页
先天性心脏病%肺动脉压力%BNP
先天性心髒病%肺動脈壓力%BNP
선천성심장병%폐동맥압력%BNP
Congenital heart disease%Pulmonary artery pressure%B-type natriuretic peptide
目的研究先天性心脏病患儿围手术期肺动脉压力和B型脑钠肽之间的关系。方法选择自2010年1月至2013年6月在我院住院的先天性心脏病患儿68例，入院后24小时内和术后1周分别测定BNP和采用心超测定肺动脉压力，然后根据入院时肺动脉压力分组，分为 PAP≤30 mmHg 组，30 mmHg＜PAP＜90 mmHg，PAP≥90 mmHg三组。结果在入选的先天性心脏病患儿中，术前PAP≤30 mmHg组BNP（186±11．2）pg/ml，明显低于30 mmHg＜PAP＜90 mmHg组（835±46．8）pg/ml，后者又明显低于PAP≥90 mmHg组（1104．5±69．3）pg/ml，（P＜0．01）。术后三组肺动脉压力均较术前明显下降，分别为（16．8±1．5）mmHg，（17．2±1．6）mmHg，（17．8±1．9）mmHg。术后三组BNP分别为（140±9．1）pg/ml，（145±10．3）pg/ml，（151±10．6）pg/ml。结论先天性心脏病患儿在手术矫正血液分流前，肺动脉压力和BNP密切相关，肺动脉压力越高，BNP水平也越高。术后随着血液动力学改善，肺动脉压力较术前迅速改善，BNP水平也明显下降。术后BNP水平高低与术前肺动脉压力无明显相关性。
目的研究先天性心髒病患兒圍手術期肺動脈壓力和B型腦鈉肽之間的關繫。方法選擇自2010年1月至2013年6月在我院住院的先天性心髒病患兒68例，入院後24小時內和術後1週分彆測定BNP和採用心超測定肺動脈壓力，然後根據入院時肺動脈壓力分組，分為 PAP≤30 mmHg 組，30 mmHg＜PAP＜90 mmHg，PAP≥90 mmHg三組。結果在入選的先天性心髒病患兒中，術前PAP≤30 mmHg組BNP（186±11．2）pg/ml，明顯低于30 mmHg＜PAP＜90 mmHg組（835±46．8）pg/ml，後者又明顯低于PAP≥90 mmHg組（1104．5±69．3）pg/ml，（P＜0．01）。術後三組肺動脈壓力均較術前明顯下降，分彆為（16．8±1．5）mmHg，（17．2±1．6）mmHg，（17．8±1．9）mmHg。術後三組BNP分彆為（140±9．1）pg/ml，（145±10．3）pg/ml，（151±10．6）pg/ml。結論先天性心髒病患兒在手術矯正血液分流前，肺動脈壓力和BNP密切相關，肺動脈壓力越高，BNP水平也越高。術後隨著血液動力學改善，肺動脈壓力較術前迅速改善，BNP水平也明顯下降。術後BNP水平高低與術前肺動脈壓力無明顯相關性。
목적연구선천성심장병환인위수술기폐동맥압력화B형뇌납태지간적관계。방법선택자2010년1월지2013년6월재아원주원적선천성심장병환인68례，입원후24소시내화술후1주분별측정BNP화채용심초측정폐동맥압력，연후근거입원시폐동맥압력분조，분위 PAP≤30 mmHg 조，30 mmHg＜PAP＜90 mmHg，PAP≥90 mmHg삼조。결과재입선적선천성심장병환인중，술전PAP≤30 mmHg조BNP（186±11．2）pg/ml，명현저우30 mmHg＜PAP＜90 mmHg조（835±46．8）pg/ml，후자우명현저우PAP≥90 mmHg조（1104．5±69．3）pg/ml，（P＜0．01）。술후삼조폐동맥압력균교술전명현하강，분별위（16．8±1．5）mmHg，（17．2±1．6）mmHg，（17．8±1．9）mmHg。술후삼조BNP분별위（140±9．1）pg/ml，（145±10．3）pg/ml，（151±10．6）pg/ml。결론선천성심장병환인재수술교정혈액분류전，폐동맥압력화BNP밀절상관，폐동맥압력월고，BNP수평야월고。술후수착혈액동역학개선，폐동맥압력교술전신속개선，BNP수평야명현하강。술후BNP수평고저여술전폐동맥압력무명현상관성。
Objective To study the relationship between perioperative pulmonary artery pressure and B-type natriuretic peptide in children with congenital heart disease .Methods 68 cases those who suffered from congenital heart disease were selected from our hospital during January 2010 and June 2013,BNP and pulmonary artery pressure were measured within 24 hours after admission and 1 week after surgery , then they were divided into PAP ≤30mmHg group, 30mmHg <PAP <90mmHg group and PAP≥90 mmHg group according to pulmonary artery pressure measured at the time of admission .Results In selected children with congenital heart disease, preoperative concentration of BNP of PAP ≤30mmHg group was 186 ±11.2pg/ml, which was significantly lower than 30mmHg<PAP<90mmHg group (835 ±46.8pg/ml), also significantly lower than the PAP≥90mmHg group (1104.5 ±69.3.8pg/ml)(P<0.01).Pulmonary artery pressure significantly decreased respectively compared with that of preoperative ( 16 ±1.5mmHg, 18 ±1.8mmHg, 20 ±2.1mmHg.BNP concentrations of the three groups were (130 ±9.1pg/ml, 145 ±10.3pg/ml, 161 ±10.3pg/ml) after operation. Conclusions Pulmonary artery pressure and BNP was positively related before surgical treatment , but there was no significant correlation between them postoperative .
