CAJ | 학술논문

目的：探讨小剂量他巴唑治疗甲状腺功能亢进症的临床疗效。方法选取雅安市第二人民医院收治的46例甲状腺功能亢进症患者，随机均分为对照组（大剂量他巴唑治疗，初始剂量：10 mg/次，3次/d，后改为10 mg/次，1次/d）和观察组（小剂量他巴唑治疗，剂量：15 mg/次，1次/d）。比较2组治疗前后血清游离三碘甲腺原氨酸FT 3、血清游离甲状腺素FT 4、促甲状腺激素TSH水平的变化、治疗总有效率和不良反应发生率的差异。结果观察组患者治疗后血清FT 3、FT 4、TSH水平和治疗总有效率分别为（10.95±1.23）μmol/L、（21.33±3.28）μmol/L、（0.27±0.05）mU/L、91.3%，与对照组比较差异无统计学意义；观察组不良反应发生率为17.4%，显著低于对照组的47.8%（P<0.05）。结论小剂量他巴唑治疗甲亢疗效确切，和大剂量比较无明显差异，小剂量他巴唑不良反应少。
목적：탐토소제량타파서치료갑상선공능항진증적림상료효。방법선취아안시제이인민의원수치적46례갑상선공능항진증환자，수궤균분위대조조（대제량타파서치료，초시제량：10 mg/차，3차/d，후개위10 mg/차，1차/d）화관찰조（소제량타파서치료，제량：15 mg/차，1차/d）。비교2조치료전후혈청유리삼전갑선원안산FT 3、혈청유리갑상선소FT 4、촉갑상선격소TSH수평적변화、치료총유효솔화불량반응발생솔적차이。결과관찰조환자치료후혈청FT 3、FT 4、TSH수평화치료총유효솔분별위（10.95±1.23）μmol/L、（21.33±3.28）μmol/L、（0.27±0.05）mU/L、91.3%，여대조조비교차이무통계학의의；관찰조불량반응발생솔위17.4%，현저저우대조조적47.8%（P<0.05）。결론소제량타파서치료갑항료효학절，화대제량비교무명현차이，소제량타파서불량반응소。
Objective To investigate the clinical effect of low-dose methimazole for the treatment of hyperthyroidism. Methods 46 cases of hyperthyroidism patients in our hospital were randomly divided into control group (received large-does methimazole therapy) and observation group (received low-dose methimazole therapy). The serum free tri-iodothyronine (FT 3), free thyroxine (FT 4), thyroid srimulating hormone (TSH) and levels before and after treatment, total effective rate and adverse reactions rate of two groups were compared. Results The serum FT 3, FT 4,TSH levels after treatment and total effective rate of two groups had no significantly difference. The adverse reactions rate of observation group was 17.4%, which was significantly lower than 47.8%of control group (P<0.05). Conclusion Both low-dose and large-does methimazole are effective for hyperthyroidism. They have no significantly difference in clinical effect while low-dose methimazole has a lower adverse reactions rate.