CAJ | 학술논문

目的：分析新辅助化疗治疗穿孔型胃癌的效果。方法选取2010年1月～2012年12月广东省高州市人民医院收治的88例穿孔型胃癌患者，将其平均分成对照组和观察组2组，对照组采用D2根治术治疗，观察组采用新辅助化疗治疗后再行D2根治术治疗，比较分析2组患者的临床疗效。结果观察组患者进行2～4个疗程的辅助化疗治疗以后，根据CT显示,观察组治疗总有效率为63.6%，对照组总有效率为31.8%，2组经统计学分析，差异具有统计学意义(P<0.05)。但是在随访的过程中，2组患者的生存率比较，差异无统计学意义。结论穿孔型胃癌患者采用新辅助化疗治疗后行D2根治术治疗短期内可改善患者临床症状，但长期效果和D2胃癌根治术相差无几。
목적：분석신보조화료치료천공형위암적효과。방법선취2010년1월～2012년12월광동성고주시인민의원수치적88례천공형위암환자，장기평균분성대조조화관찰조2조，대조조채용D2근치술치료，관찰조채용신보조화료치료후재행D2근치술치료，비교분석2조환자적림상료효。결과관찰조환자진행2～4개료정적보조화료치료이후，근거CT현시,관찰조치료총유효솔위63.6%，대조조총유효솔위31.8%，2조경통계학분석，차이구유통계학의의(P<0.05)。단시재수방적과정중，2조환자적생존솔비교，차이무통계학의의。결론천공형위암환자채용신보조화료치료후행D2근치술치료단기내가개선환자림상증상，단장기효과화D2위암근치술상차무궤。
Objective To analyze the effect of neoadjuvant chemotherapy in the treatment of perforated gastric cancer. Methods 88 cases of perforating gastric cancer in the hospital from January 2010 to December 2012 were chosen, the patients were divided into the observation group and the control group, control group received by D 2 radical mastectomy, observation group was treated with neoadjuvant chemotherapy after radical surgery for D 2, the clinical efifcacy of two groups were compared. Results The patients in the observation group into (2-4) combined with chemotherapy in the treatment of treatment.According to CT evaluation,the total effective rate of observation group was 63.6%,while that of control group was 31.8%.There was signiifcant difference between two groups (P<0.05). But in the process of follow-up, survival rate of two groups were compared, the difference was no signiifcant. Conclusion Perforating gastric cancer treated with neoadjuvant chemotherapy in the treatment of D 2 after radical mastectomy could improve Clinical symptoms,but there was not much difference between D 2 and neoadjuvant chemotherapy after radical surgery for D 2.