中国临床保健杂志
中國臨床保健雜誌
중국림상보건잡지
CHINESE JOURNAL OF CLINICAL HEALTHCARE
2014年
4期
367-369
,共3页
糖尿病,2型%羟基胆骨化醇类%糖尿病肾病%白蛋白尿
糖尿病,2型%羥基膽骨化醇類%糖尿病腎病%白蛋白尿
당뇨병,2형%간기담골화순류%당뇨병신병%백단백뇨
Diabetes Mellitus,Type 2%Hydroxycholecalciferols%Diabetic nephropathies%Albuminuria
目的：探讨2型糖尿病（T2DM）患者血清25羟维生素D[25（OH）D]水平与糖尿病肾病的关系。方法选取住院的T2DM患者239例，根据尿白蛋白/尿肌酐（UACR）水平分为正常白蛋白尿组、微量白蛋白尿组和大量白蛋白尿组，比较各组的血清25（OH）D水平。以血清25（OH）D＝20μg/L为界进行分组，将上述患者分为维生素D缺乏组（＜20μg/L）和维生素D不足组（≥20且＜30μg/L），比较两组白蛋白尿发生率。结果与正常蛋白尿组比较，微量和大量白蛋白尿组的血清25（OH）D水平更低（P＜0．01），与微量白蛋白尿组比较，大量白蛋白尿组的血清25（OH）D水平更低（P＜0．01）；维生素D缺乏组和维生素D不足组白蛋白尿发生率分别为68．5％、39．4％（P＜0．01）；相关分析显示血清25（OH）D水平与UACR负相关。结论血清低维生素D水平参与了2型糖尿病肾损害的发生有关。
目的：探討2型糖尿病（T2DM）患者血清25羥維生素D[25（OH）D]水平與糖尿病腎病的關繫。方法選取住院的T2DM患者239例，根據尿白蛋白/尿肌酐（UACR）水平分為正常白蛋白尿組、微量白蛋白尿組和大量白蛋白尿組，比較各組的血清25（OH）D水平。以血清25（OH）D＝20μg/L為界進行分組，將上述患者分為維生素D缺乏組（＜20μg/L）和維生素D不足組（≥20且＜30μg/L），比較兩組白蛋白尿髮生率。結果與正常蛋白尿組比較，微量和大量白蛋白尿組的血清25（OH）D水平更低（P＜0．01），與微量白蛋白尿組比較，大量白蛋白尿組的血清25（OH）D水平更低（P＜0．01）；維生素D缺乏組和維生素D不足組白蛋白尿髮生率分彆為68．5％、39．4％（P＜0．01）；相關分析顯示血清25（OH）D水平與UACR負相關。結論血清低維生素D水平參與瞭2型糖尿病腎損害的髮生有關。
목적：탐토2형당뇨병（T2DM）환자혈청25간유생소D[25（OH）D]수평여당뇨병신병적관계。방법선취주원적T2DM환자239례，근거뇨백단백/뇨기항（UACR）수평분위정상백단백뇨조、미량백단백뇨조화대량백단백뇨조，비교각조적혈청25（OH）D수평。이혈청25（OH）D＝20μg/L위계진행분조，장상술환자분위유생소D결핍조（＜20μg/L）화유생소D불족조（≥20차＜30μg/L），비교량조백단백뇨발생솔。결과여정상단백뇨조비교，미량화대량백단백뇨조적혈청25（OH）D수평경저（P＜0．01），여미량백단백뇨조비교，대량백단백뇨조적혈청25（OH）D수평경저（P＜0．01）；유생소D결핍조화유생소D불족조백단백뇨발생솔분별위68．5％、39．4％（P＜0．01）；상관분석현시혈청25（OH）D수평여UACR부상관。결론혈청저유생소D수평삼여료2형당뇨병신손해적발생유관。
Objective To explore the correlation between serum 25-hydroxyvitamin D[25(OH)D]level and diabetic nephropathy in type 2 diabetics.Methods 239 diabetic hospitalized patients were enrolled into the study . They were divided into normoalbuminuria group , microalbuminuria group and macro-albuminuria group according to the ratio of urinary albumin to creatinine ratio (UACR).All patients were divided into vitamin D deficiency (<20μg/L) group and vitamin D insufficiency(≥20-<30μg/L) group according to the level of 25(OH)D=20μg/L.The incidence of albuminuria between the two groups was compared .Results Compared with the patients in normoalbu-minuria group,patients in microalbuminuria group and macroalbuminuria group showed a lower level of serum 25 (OH)D(P <0.01).Compared with the patients in microalbuminuria group ,patients in macroalbuminuria group showed a lower level of serum 25(OH)D (P<0.01).The incidence of albuminuria in vitamin D deficiency group and vitamin D insufficiency group was 68.5%and 39.4%(P<0.01),respectively.Correlation analysis revealed that the level of serum 25 ( OH) D was negatively correlated with UACR .Conclusion The reduction of vitamin D level in vivo may be associated with the development of diabetic nephropathy in patients with type 2 diabetes mellitus .
