临床精神医学杂志
臨床精神醫學雜誌
림상정신의학잡지
JOURNAL OF CLINICAL PSYCHOLOGICAL MEDICINE
2014年
4期
261-262
,共2页
谢焱%周芳珍%雷黎%覃电泽
謝焱%週芳珍%雷黎%覃電澤
사염%주방진%뢰려%담전택
精神分裂症%哌罗匹隆%利培酮%糖脂代谢
精神分裂癥%哌囉匹隆%利培酮%糖脂代謝
정신분렬증%고라필륭%리배동%당지대사
schizophrenia%perospirone%risperidone%glucose and lipid metabolism
目的：探讨哌罗匹隆治疗老年期首发精神分裂症的疗效及其对体质量、糖脂代谢的影响。方法：72例老年期首发精神分裂症患者随机分为哌罗匹隆组和利培酮组并予以相应的药物治疗8周。治疗前后进行阳性和阴性症状量表（PANSS）、临床总体印象量表（CGI-SI）及治疗中出现的症状量表（TESS）评定，以及体质量、血糖、血脂测定。结果：治疗后哌罗匹隆组总有效率（83.33±）与利培酮组（80.56±）差异无统计学意义（χ2＝0.094，P ﹥0.05）；哌罗匹隆组低密度脂蛋白水平较治疗前明显增加（P ﹤0.05）；利培酮组体质量、空腹血糖、餐后2 h 血糖、血三酰甘油、总胆固醇及低密度脂蛋白水平较治疗前明显增加，高密度脂蛋白水平明显降低（P ﹤0.05或 P ﹤0.01）；两组 TESS 评分差异无统计学意义。结论：哌罗匹隆治疗老年期首发精神分裂症的疗效与利培酮相当，对体质量、糖脂代谢影响较小。
目的：探討哌囉匹隆治療老年期首髮精神分裂癥的療效及其對體質量、糖脂代謝的影響。方法：72例老年期首髮精神分裂癥患者隨機分為哌囉匹隆組和利培酮組併予以相應的藥物治療8週。治療前後進行暘性和陰性癥狀量錶（PANSS）、臨床總體印象量錶（CGI-SI）及治療中齣現的癥狀量錶（TESS）評定，以及體質量、血糖、血脂測定。結果：治療後哌囉匹隆組總有效率（83.33±）與利培酮組（80.56±）差異無統計學意義（χ2＝0.094，P ﹥0.05）；哌囉匹隆組低密度脂蛋白水平較治療前明顯增加（P ﹤0.05）；利培酮組體質量、空腹血糖、餐後2 h 血糖、血三酰甘油、總膽固醇及低密度脂蛋白水平較治療前明顯增加，高密度脂蛋白水平明顯降低（P ﹤0.05或 P ﹤0.01）；兩組 TESS 評分差異無統計學意義。結論：哌囉匹隆治療老年期首髮精神分裂癥的療效與利培酮相噹，對體質量、糖脂代謝影響較小。
목적：탐토고라필륭치료노년기수발정신분렬증적료효급기대체질량、당지대사적영향。방법：72례노년기수발정신분렬증환자수궤분위고라필륭조화리배동조병여이상응적약물치료8주。치료전후진행양성화음성증상량표（PANSS）、림상총체인상량표（CGI-SI）급치료중출현적증상량표（TESS）평정，이급체질량、혈당、혈지측정。결과：치료후고라필륭조총유효솔（83.33±）여리배동조（80.56±）차이무통계학의의（χ2＝0.094，P ﹥0.05）；고라필륭조저밀도지단백수평교치료전명현증가（P ﹤0.05）；리배동조체질량、공복혈당、찬후2 h 혈당、혈삼선감유、총담고순급저밀도지단백수평교치료전명현증가，고밀도지단백수평명현강저（P ﹤0.05혹 P ﹤0.01）；량조 TESS 평분차이무통계학의의。결론：고라필륭치료노년기수발정신분렬증적료효여리배동상당，대체질량、당지대사영향교소。
To explore the efficacy of perospirone and its influence on body mass,glucose and lipid metabolism in first-episode elderly schizophrenic patients. Method:Seventy-two first episode elderly schizophrenic patients were randomly divided into perospirone group and risperidone group,and treated with cor-responding drug for 8 weeks. Efficacy and adverse events were assessed by positive and negative symptom scale (PANSS),clinical global impression scale(CGI-SI)and treatment emergent symptom scale(TESS)before and and after treatment. While,the body mass,blood sugar and blood lipid were detected. Results:The total effi-ciency between perospirone group(83. 33± )and risperidone group(80. 56± )was not significantly different (χ2 = 0. 094,P ﹥ 0. 05). The level of low density lipoprotein in perospirone group was significantly increased than before treatment(P ﹤ 0. 05). The body mass,the levels of fasting plasma glucose,2 h postprandial glu-cose,triglyceride,total cholesterol and low density lipoprotein in risperidone group were significantly increased, the level of high density lipoprotein was significantly decreased than before treatment(P ﹤ 0. 05 or P ﹤ 0. 01). Conclusion:The efficiency of perospirone in first episode elderly schizophrenic patients is equal as risperi-done,and its influence on body mass,glucose and lipid metabolism is smaller.
