CAJ | 학술논문

目的：探讨伴有抑郁老年冠心病患者自主神经功能的改变。方法：根据汉密尔顿抑郁量表（HAMD）、Zung 氏抑郁自评量表（SDS）、以及冠状动脉造影结果，将163例住院患者及健康体检者分为冠心病伴抑郁组（48例）、冠心病组（65例）、正常对照组（50例）；并行24 h 动态心电图检查，分析心率变异各项指标及其与抑郁程度的相关性。结果：与正常对照组相比，冠心病伴抑郁组与单纯冠心病组，时域指标均下降，频域指标中低频功率（LF）、LF/高频功率（HF）值上升。冠心病伴抑郁组的抑郁严重度与24 h 正常 RR 间期标准差（SDNN）呈负相关，与 LF/ HF 之间呈正相关（r ＝-0.967，r ＝0.971，P 均﹤0.05）。结论：伴有抑郁症状老年冠心病患者自主神经功能改变更明显，并与抑郁程度相关。
목적：탐토반유억욱노년관심병환자자주신경공능적개변。방법：근거한밀이돈억욱량표（HAMD）、Zung 씨억욱자평량표（SDS）、이급관상동맥조영결과，장163례주원환자급건강체검자분위관심병반억욱조（48례）、관심병조（65례）、정상대조조（50례）；병행24 h 동태심전도검사，분석심솔변이각항지표급기여억욱정도적상관성。결과：여정상대조조상비，관심병반억욱조여단순관심병조，시역지표균하강，빈역지표중저빈공솔（LF）、LF/고빈공솔（HF）치상승。관심병반억욱조적억욱엄중도여24 h 정상 RR 간기표준차（SDNN）정부상관，여 LF/ HF 지간정정상관（r ＝-0.967，r ＝0.971，P 균﹤0.05）。결론：반유억욱증상노년관심병환자자주신경공능개변경명현，병여억욱정도상관。
To explore the changes of autonomic nervous function in elderly coronary heart disease(CHD)patients accompanied by depression. Method:According to the scores of Hamilton depres-sion rating scale(HAMD),Zung self-rating depression scale(SDS),and the results of coronary angiography, 163 inpatients and health persons were divided into CHD with depression group(48 cases),CHD group(65 ca-ses)and normal control(NC)group(50 cases). They were monitoried by 24 h dynamic electrocardiogram. The index of heart rate variability(HRV)and its correlation with depressive severity were analyzed. Results:Compared to NC group,the time domain index of HRV were significantly lower;the mean value of the low-fre-quency(LF)power in the frequency domain index,and the value of LF/ high-frequency(HF)power were signif-icantly increased in CHD with depression group and CHD group. The depressive severity was negatively correlated with 24 h normal phase standard deviation(SDNN)and positive correlated with LF/ HF in CHD patients accom-panied by depression(r = - 0. 967,r = 0. 971,all P ﹤ 0. 05). Conclusion:The change of autonomic nervous function in CHD patients accompanied by depression is more obvious and correlated with depressive severity.