CAJ | 학술논문

目的：探讨乙型肝炎病毒X基因（HBX）在涎腺腺样囊性癌（ACC）中的表达及意义。方法选取2008年6月-2012年10月就诊于昆明医科大学附属口腔医院口腔颌面外科的涎腺肿瘤患者为研究对象。血清学结果HBeAg无论是阳性或阴性，以HBeAb阳性为HBV携带者或曾感染者。根据术后病理结果分为ACC组和对照组，采用免疫组织化学及聚合酶链反应（PCR）技术检测两组组织中HBX的表达。结果 HBX大多数表达于细胞质内，小部分表达于胞核内。HBX在ACC中表达强度强于涎腺腺淋巴瘤，二者间差异有统计学意义。结论 HBX在ACC的发生、发展中可能起重要作用。
목적：탐토을형간염병독X기인（HBX）재연선선양낭성암（ACC）중적표체급의의。방법선취2008년6월-2012년10월취진우곤명의과대학부속구강의원구강합면외과적연선종류환자위연구대상。혈청학결과HBeAg무론시양성혹음성，이HBeAb양성위HBV휴대자혹증감염자。근거술후병리결과분위ACC조화대조조，채용면역조직화학급취합매련반응（PCR）기술검측량조조직중HBX적표체。결과 HBX대다수표체우세포질내，소부분표체우포핵내。HBX재ACC중표체강도강우연선선림파류，이자간차이유통계학의의。결론 HBX재ACC적발생、발전중가능기중요작용。
Objective To explore the expression of hepatitis B-virus X gene (HBX) in adenoid cystic carcinoma (ACC) and determine its clinical significance. Methods Between June 2008 and October 2012, in-hospital patients with salivary gland tumors who were treated at the Department of Oral and Maxillofacial Surgery, Affiliated Stomatology Hospital of Kunming Medical University, were enrolled to this study. HBeAb-positive patients were defined as those exposed to hepatitis B virus (HBV) or harboring persistent HBV infection regardless of being HBeAg positive or negative. According to the pathological results, all patients were divided into ACC group and control group. Immunohistochemical staining and polymerase chain reaction (PCR) were used to detect HBX expression in ACC group and control group. Results HBX expression was mostly detected in the cytoplasm of ACC cells. Minimal HBX expression was detected in the nucleus. HBX expression was significantly higher in ACC than in Warthin’s tumor. A significant difference was observed between the two groups. Conclusion HBX is expressed in ACC and may be associated with the development of ACC. HBX might serve important functions in the carcinogenesis and development of ACC.