CAJ | 학술논문

目的：探讨奥司他韦抗病毒药治疗疑似甲流的安全性、有效性。方法：将60例疑似甲流患者随机平均分成2组：实验组口服奥司他韦治疗；对照组口服利巴韦林治疗。评估比较2组的流感症状缓解情况及症状消失时间。结果：实验组的临床有效率93.33%，明显高于对照组的70.00%（P<0.05）。实验组的退热时间以及其他主要症状平均消失时间明显短于对照组（P<0.05），实验组治疗5d后发热、咽喉痛、鼻塞、咳嗽、头痛、肌肉关节痛、发冷/出汗、乏力等症状的缓解率明显高于对照组（P<0.05）；实验组的不良反应发生率13.33%，明显低于对照组36.67%（P<0.05）。结论：奥司他韦抗病毒用于治疗疑似甲流安全、有效，且效果好于利巴韦林。
목적：탐토오사타위항병독약치료의사갑류적안전성、유효성。방법：장60례의사갑류환자수궤평균분성2조：실험조구복오사타위치료；대조조구복리파위림치료。평고비교2조적류감증상완해정황급증상소실시간。결과：실험조적림상유효솔93.33%，명현고우대조조적70.00%（P<0.05）。실험조적퇴열시간이급기타주요증상평균소실시간명현단우대조조（P<0.05），실험조치료5d후발열、인후통、비새、해수、두통、기육관절통、발랭/출한、핍력등증상적완해솔명현고우대조조（P<0.05）；실험조적불량반응발생솔13.33%，명현저우대조조36.67%（P<0.05）。결론：오사타위항병독용우치료의사갑류안전、유효，차효과호우리파위림。
To investigate the safety and effectiveness of antiviral oseltamivir for treatment of suspected influenza. Methods: The 60 cases of suspected influenza patients were randomly divided into two groups, control group (n=30) and treatment group (n=30). The control group was given ribavirin, and the treatment group was given oseltamivir. The remission and disappear time of influenza symptoms in the 2 groups were observed and compared. Results: The total efficiency rate was 93.33% vs 70.00% in the treatment group vs the control group(P<0.05); the time of temperature returned to normal and the disappear time of other influenza symptoms in the treatment group were significantly shorter than those in the control group (P<0.05); the symptoms remission rates of fever, sore throat, nasal congestion, cough, headache, muscle and joint pain, chills/sweats and fatigue in the treatment group after 5 days were significantly high-er than those in the control group (P<0.05); the incidence of adverse reactions was 13.33% vs 36.67% in the treatment group vs the control group (P<0.05). Conclusion: Antiviral oseltamivir for the treatment of suspected influenza is safe and effective.