中国医学前沿杂志(电子版)
中國醫學前沿雜誌(電子版)
중국의학전연잡지(전자판)
CHINESE JOURNAL OF THE FRONTIERS OF MEDICAL SCIENCE(ELECTRONIC VERSION)
2014年
7期
131-133
,共3页
急性白血病%免疫干细胞%表型%疗效
急性白血病%免疫榦細胞%錶型%療效
급성백혈병%면역간세포%표형%료효
Acute leukemia%Immune cells%Phenotype%The curative effect
目的:研究不同免疫干细胞表型的急性白血病患者的治疗效果及预后情况。方法将本院2010年1月至2013年12月收治的78例急性白血病患者作为研究对象,检测其免疫干细胞表型,并记录治疗情况。结果急性白血病免疫干细胞表型CD34+的患者比例最高(71.39%),其次为CD33+、CD64+患者;免疫干细胞CD33、CD64、CD34、CD19呈阳性的患者治愈率均低于其表型呈阴性的患者,差异具有显著性(t=11.1682,9.5098,10.6997,7.2341;P=0.0008,0.0020,0.0011,0.0072);免疫干细胞表型CD34+CD19+患者的治愈率高于CD34+CD19-的患者;而CD34+CD64+患者的治愈率低于CD34+CD64-的患者,差异具有显著性(t=6.9115,6.3096;P=0.0086,0.0120)。结论不同免疫干细胞表型的急性白血病患者的治愈率不同,免疫干细胞表型与急性白血病患者的治疗效果、预后密切相关。
目的:研究不同免疫榦細胞錶型的急性白血病患者的治療效果及預後情況。方法將本院2010年1月至2013年12月收治的78例急性白血病患者作為研究對象,檢測其免疫榦細胞錶型,併記錄治療情況。結果急性白血病免疫榦細胞錶型CD34+的患者比例最高(71.39%),其次為CD33+、CD64+患者;免疫榦細胞CD33、CD64、CD34、CD19呈暘性的患者治愈率均低于其錶型呈陰性的患者,差異具有顯著性(t=11.1682,9.5098,10.6997,7.2341;P=0.0008,0.0020,0.0011,0.0072);免疫榦細胞錶型CD34+CD19+患者的治愈率高于CD34+CD19-的患者;而CD34+CD64+患者的治愈率低于CD34+CD64-的患者,差異具有顯著性(t=6.9115,6.3096;P=0.0086,0.0120)。結論不同免疫榦細胞錶型的急性白血病患者的治愈率不同,免疫榦細胞錶型與急性白血病患者的治療效果、預後密切相關。
목적:연구불동면역간세포표형적급성백혈병환자적치료효과급예후정황。방법장본원2010년1월지2013년12월수치적78례급성백혈병환자작위연구대상,검측기면역간세포표형,병기록치료정황。결과급성백혈병면역간세포표형CD34+적환자비례최고(71.39%),기차위CD33+、CD64+환자;면역간세포CD33、CD64、CD34、CD19정양성적환자치유솔균저우기표형정음성적환자,차이구유현저성(t=11.1682,9.5098,10.6997,7.2341;P=0.0008,0.0020,0.0011,0.0072);면역간세포표형CD34+CD19+환자적치유솔고우CD34+CD19-적환자;이CD34+CD64+환자적치유솔저우CD34+CD64-적환자,차이구유현저성(t=6.9115,6.3096;P=0.0086,0.0120)。결론불동면역간세포표형적급성백혈병환자적치유솔불동,면역간세포표형여급성백혈병환자적치료효과、예후밀절상관。
Objective Patients with acute leukemia treatment effect and prognosis of different phenotypes of immune. Method 78 cases of acute leukemia patients in our hospital from January 2010 to December 2013 as the research object, its immune stemcell phenotype was detected, and record the treatment situation. Result Immune in patients with acute leukemia stem cell phenotype in patients with CD34+ the highest proportion (71.39%), followed by CD33+, CD64+;CD33, CD64 in patients with immune cells, CD34, CD19 positive patients, the cure rate was lower than the phenotypic negative patients, the difference was signiifcant (t=11.1682, 9.5098, 10.6997, 7.2341;P=0.0008, 0.0020, 0.0011, 0.0072);cure the patients immune stem cellphenotype of CD34+CD19+was higher than that of the CD34+CD19-patients;and the healing rate of the patients with CD34+CD64+than patients with CD34+CD64-, and the difference was signiifcant (t = 6.9115, 6.3096; P = 0.0086, 0.0120). Conclusion The cure rate of patients with acute leukemia cell phenotype different immune stem of different immune in patients with acute leukemia, stem cell phenotype, the treatment effect is closely related to the prognosis.