中国医学前沿杂志（电子版）
中國醫學前沿雜誌（電子版）
중국의학전연잡지（전자판）
CHINESE JOURNAL OF THE FRONTIERS OF MEDICAL SCIENCE(ELECTRONIC VERSION)
2014年
7期
128-130
,共3页
垂体肿瘤%症状和体征%内分泌%病理类型
垂體腫瘤%癥狀和體徵%內分泌%病理類型
수체종류%증상화체정%내분비%병리류형
Pituitary neoplasms%Symptoms and signs%Endocrine%Pathological types
目的：对垂体微腺瘤的临床症状体征、内分泌与病理免疫组化类型相关性进行探讨。方法选取2010年1月至2012年12月在本院确诊的垂体微腺瘤患者84例，对其进行内分泌、影像学和病理检查，分析检查结果之间的关系。结果患者出现内分泌症状76例（90.47%），免疫组化阳性组内分泌症状发生率[92.59%（75/81）]较免疫组化阴性组[33.33%（1/3）]高，差异具有显著性（χ2＝5.92，P＜0.05），表明内分泌症状与免疫组化结果相符。血清泌乳素（PRL）阳性组血清PRL增高及闭经、溢乳或月经失调发生率高于PRL阴性组；生长激素（GH）阳性组血清GH增高及巨人症或肢端肥大发生率高于GH阴性组。结论垂体微腺瘤患者的临床表现、内分泌结果与病理免疫组化类型相关，可用来提高垂体微腺瘤的诊断率与治疗率。
目的：對垂體微腺瘤的臨床癥狀體徵、內分泌與病理免疫組化類型相關性進行探討。方法選取2010年1月至2012年12月在本院確診的垂體微腺瘤患者84例，對其進行內分泌、影像學和病理檢查，分析檢查結果之間的關繫。結果患者齣現內分泌癥狀76例（90.47%），免疫組化暘性組內分泌癥狀髮生率[92.59%（75/81）]較免疫組化陰性組[33.33%（1/3）]高，差異具有顯著性（χ2＝5.92，P＜0.05），錶明內分泌癥狀與免疫組化結果相符。血清泌乳素（PRL）暘性組血清PRL增高及閉經、溢乳或月經失調髮生率高于PRL陰性組；生長激素（GH）暘性組血清GH增高及巨人癥或肢耑肥大髮生率高于GH陰性組。結論垂體微腺瘤患者的臨床錶現、內分泌結果與病理免疫組化類型相關，可用來提高垂體微腺瘤的診斷率與治療率。
목적：대수체미선류적림상증상체정、내분비여병리면역조화류형상관성진행탐토。방법선취2010년1월지2012년12월재본원학진적수체미선류환자84례，대기진행내분비、영상학화병리검사，분석검사결과지간적관계。결과환자출현내분비증상76례（90.47%），면역조화양성조내분비증상발생솔[92.59%（75/81）]교면역조화음성조[33.33%（1/3）]고，차이구유현저성（χ2＝5.92，P＜0.05），표명내분비증상여면역조화결과상부。혈청비유소（PRL）양성조혈청PRL증고급폐경、일유혹월경실조발생솔고우PRL음성조；생장격소（GH）양성조혈청GH증고급거인증혹지단비대발생솔고우GH음성조。결론수체미선류환자적림상표현、내분비결과여병리면역조화류형상관，가용래제고수체미선류적진단솔여치료솔。
Objective To explore the relationship between the clinical symptoms and endocrine of micro pituitary adenomas and pathological immunohistochemical type. Method We had Choosed 84 patients with micro pituitary adenomas from January 2010 to December 2012 in our hospital, then checked the endocrine, imaging and pathological of them, and analysis the relationship between the test results. Result There were 76 cases (90.47%) had endocrine symptoms in all patients, the immunohistochemical positive endocrine symptoms rate was 92.59%(75/81) , this rate was higher than the immunohistochemical negative group which rate was 33.33%(1/3), the difference was statistically signiifcant (χ2=5.92, P<0.05), this indicated that the endocrine symptoms consistent with immunohistochemical results. The increased serum PRL and amenorrhea, spilled milk or incidence of menstrual disorder rate of serum prolactin (PRL) positive group were higher than that of PRL negative groups; increased serum GH and gigantism or acromegaly fertilizer rates of growth hormone (GH) positive group were higher than GH negative groups. Conclusion The relationship between the clinical symptoms and endocrine of micro pituitary adenomas and pathological immunohistochemical type is close, this can be used to improve the diagnosis and treatment of pituitary micro adenoma.
