CAJ | 학술논문

目的：探讨前列地尔对脑血管造影术后造影剂肾病的预防作用及其使用方法。方法随机选择脑血管造影患者169例，分为对照组（49例）、前列地尔组（52例）、试验组（68例）；对照组患者接受脑血管病二级预防治疗，前列地尔组患者在对照组基础上于术前给予患者静脉滴注1次10μg前列地尔，试验组患者在对照组基础上于术前给予患者静脉滴注2次10μg前列地尔，检测三组患者术前、术后连续3天及第5天的血清肌酐、胱抑素C水平，术前及术后72小时出现尿蛋白的例数。结果试验组和对照组患者术后第24、48、72小时及第5天血清肌酐、胱抑素C升高值比较差异有显著性（P＜0.05）；试验组和前列地尔组患者第48、72小时及第5天血清肌酐、胱抑素C升高值比较差异有显著性（P＜0.05）；术后尿蛋白发生情况，试验组与对照组、前列地尔组相比均有明显差异（P＜0.05）；前列地尔组和对照组第48、72小时血清肌酐、胱抑素C升高值比较差异有显著性（P＜0.05）。结论行脑血管造影术前使用前列地尔注射液，能有效改善患者术后肾功能，降低术后造影剂肾病的发生率，具有较高的临床应用价值。
목적：탐토전렬지이대뇌혈관조영술후조영제신병적예방작용급기사용방법。방법수궤선택뇌혈관조영환자169례，분위대조조（49례）、전렬지이조（52례）、시험조（68례）；대조조환자접수뇌혈관병이급예방치료，전렬지이조환자재대조조기출상우술전급여환자정맥적주1차10μg전렬지이，시험조환자재대조조기출상우술전급여환자정맥적주2차10μg전렬지이，검측삼조환자술전、술후련속3천급제5천적혈청기항、광억소C수평，술전급술후72소시출현뇨단백적례수。결과시험조화대조조환자술후제24、48、72소시급제5천혈청기항、광억소C승고치비교차이유현저성（P＜0.05）；시험조화전렬지이조환자제48、72소시급제5천혈청기항、광억소C승고치비교차이유현저성（P＜0.05）；술후뇨단백발생정황，시험조여대조조、전렬지이조상비균유명현차이（P＜0.05）；전렬지이조화대조조제48、72소시혈청기항、광억소C승고치비교차이유현저성（P＜0.05）。결론행뇌혈관조영술전사용전렬지이주사액，능유효개선환자술후신공능，강저술후조영제신병적발생솔，구유교고적림상응용개치。
Objective To investigate the preventive effect of alprostadil on contrast-induced nephropathy after cerebral angiography and methods of use. Method 169 cases of patients underwent cerebral angiography were randomly divided into three groups, the control group (49 cases), alprostadil group (52 cases), and the experimental group (68 cases). Patients in the control group accepted therapy for secondary prevention of cerebrovascular disease, patients in the alprostadil group based on the control group, were given intravenous infusion of 10μg alprostadil before surgery once, and the experimental group were intravenously administered 10μg alprostadil twice on the basis of the control group, 3, 5 days, depending on the patient's condition decision. Three groups were detected before and after surgery for 3 days and 5 days of serum creatinine, cystatin C levels, preoperative and postoperative 72 hours appeared several cases of urinary protein. Result Experimental group and the control group patients and third ifve days 24, 48, 72 hours serum creatinine, cystatin C increased the value of the difference was signiifcant (P<0.05);alprostadil test group and 48 patients, 72 hours and the second ifve days of serum creatinine, cystatin C increased the value of the difference was statistically signiifcant (P<0.05);In the aspect of postoperative incidence of urinary protein test group and the control group, alprostadil group were signiifcantly different (P<0.05);alprostadil group and the control group at 48 and 72 hours in serum creatinine, cystatin C increased the value of the difference was statistically signiifcant (P<0.05). Conclusion Before the treatment of cerebral angiography using alprostadil, can effectively improve renal function, reduce the incidence of postoperative contrast-induced nephropathy, with high clinical value.