CAJ | 학술논문

载脂蛋白A-I（ApoA-I）是载脂蛋白A家族中最早发现的蛋白，在脂质代谢过程中具有重要作用，主要参与胆固醇的合成及转运。ApoA-I与高脂血症及动脉粥样硬化的发生息息相关，临床上已经将血浆 ApoA-I/ApoB 作为高脂血症的指标之一。本文就 ApoA-I 基因多态性及其对胆固醇合成逆转（RCT）关系的研究进展进行综述。
재지단백A-I（ApoA-I）시재지단백A가족중최조발현적단백，재지질대사과정중구유중요작용，주요삼여담고순적합성급전운。ApoA-I여고지혈증급동맥죽양경화적발생식식상관，림상상이경장혈장 ApoA-I/ApoB 작위고지혈증적지표지일。본문취 ApoA-I 기인다태성급기대담고순합성역전（RCT）관계적연구진전진행종술。
Apolipoprotein A-I (apoA-I) is a member of the apolipoprotein A family, which was discovered the earli-est. It has an important role in the regulation of lipid metabolism, which mainly includes cholesterol synthesis and transfer. Therefore, apoA-I is closely related to hyperlipidemia and atherosclerosis. Clinically, serum ApoA-I/ApoB has been used as one of the indexes of hyperlipidemia. This article reviewed the study progress in ApoA-I's gene polymorphism and its relationship with reverse cholesterol transport (RCT).