CAJ | 학술논문

目的：探讨栀子苷对高尿酸血症小鼠的影响。方法：用氧嗪酸钾连续7天灌胃造成小鼠高尿酸血症模型，同时每天灌胃栀子苷（50、100、200 mg·kg-1），检测小鼠血清尿酸（SUA）、尿尿酸（UUA）、肝脏黄嘌呤氧化酶活性（XOD）。结果：栀子苷中、高剂量能显著降低高尿酸血症小鼠血清尿酸水平（P<0.01）。结论：栀子苷可通过促进尿酸排泄降低高尿酸血症小鼠的血清尿酸水平。
목적：탐토치자감대고뇨산혈증소서적영향。방법：용양진산갑련속7천관위조성소서고뇨산혈증모형，동시매천관위치자감（50、100、200 mg·kg-1），검측소서혈청뇨산（SUA）、뇨뇨산（UUA）、간장황표령양화매활성（XOD）。결과：치자감중、고제량능현저강저고뇨산혈증소서혈청뇨산수평（P<0.01）。결론：치자감가통과촉진뇨산배설강저고뇨산혈증소서적혈청뇨산수평。
This article was aimed to study the effect of geniposide in hyperuricemia mice. Different doses (50, 100, 200 mg·kg-1) of geniposide were administrated to hyperuricemia mice induced by potassium oxonate by gavage for seven consecutive days. Then, serum uric acid (SUA), urinary uric acid (UUA) and the hepatic xanthine oxidase ac-tivities (XOD) of mice were detected. The results showed that the middle- and high-dose groups of geniposide re-duced the level of SUA significantly (P<0.01). It was concluded that geniposide can reduce the level of SUA in hy-peruricemia mice by promoting UUA excretion.