CAJ | 학술논문

目的：探讨短周期多次经尿道深度电切联合膀胱灌注化疗治疗高龄高危T2期浸润性膀胱癌的疗效。方法2011年1月～2013年5月对45例高龄高危T2期浸润性膀胱癌采用2～4次经尿道深度电切联合膀胱灌注化疗，电切间隔时间4～6周，电切深度至脂肪层。结果手术时间15～65 min，平均31 min。6例因肿瘤较大[（3．7±0．4） cm]行短周期4次电切，19例[肿瘤大小（3．2±0．5） cm]行短周期3次电切，20例[肿瘤大小（2．3±0．6） cm]行短周期2次电切。45例随访4～29个月，复发率24．4％（11/45），转移率11．1％（5/45），病死率8．9％（4/45）。结论短周期多次经尿道深度电切联合膀胱灌注化疗治疗高龄高危T2期浸润性膀胱癌疗效确切，方法简单，可重复性强，对于不能耐受或不愿接受根治性膀胱全切的患者，是一种可以谨慎选择的手术治疗方案。
목적：탐토단주기다차경뇨도심도전절연합방광관주화료치료고령고위T2기침윤성방광암적료효。방법2011년1월～2013년5월대45례고령고위T2기침윤성방광암채용2～4차경뇨도심도전절연합방광관주화료，전절간격시간4～6주，전절심도지지방층。결과수술시간15～65 min，평균31 min。6례인종류교대[（3．7±0．4） cm]행단주기4차전절，19례[종류대소（3．2±0．5） cm]행단주기3차전절，20례[종류대소（2．3±0．6） cm]행단주기2차전절。45례수방4～29개월，복발솔24．4％（11/45），전이솔11．1％（5/45），병사솔8．9％（4/45）。결론단주기다차경뇨도심도전절연합방광관주화료치료고령고위T2기침윤성방광암료효학절，방법간단，가중복성강，대우불능내수혹불원접수근치성방광전절적환자，시일충가이근신선택적수술치료방안。
Objective-To-probe-into-the-effects-of-multiple-short-cycle-transurethral-deep-ablation-combined-with-intravesical-instillation-chemotherapy-for-high-risk-T2-stage-invasive-bladder-cancer-in-senile-patients-.-Methods-A-total-of-45-senile-patients-with-high-risk-T2-stage-invasive-bladder-cancer-from-January-2011-to-May-2013-were-given-transurethral-deep-ablation-combined-with-chemotherapy-of-intravesical-instillation-every-4--6-weeks,-totally-2--4-times,-until-the-depth-of-ablation-reaching-the-fat-layer-.-Results-The-operation-time-was-15--65-min-(-mean,-31-min).Among-them,-6-patients-with-relatively-large-tumors-(-diameter,-3.7-±0.4-cm)-were-given-short-cycle-transurethral-deep-ablation-for-4-times,-19-patients-(diameter,-3.2-±0.5-cm)-for-3-times,and-20-patients-(diameter,-2.3-±0.6-cm)-for-2-times.All-the-patients-were-followed-up-for-4--29-months.The-postoperative-recurrencerate-was-24.4%-(11/45),-the-metastasis-rate-was-11.1%-(5/45),-and-the-death-rate-was-8.9%-(5/45).-Conclusions-Multiple-short-cycle-transurethral-deep-ablation-combined-with-intravesical-instillation-chemotherapy-for-high--risk-T2-stage-invasive-bladder-cancer-is-effective,-repeatable,-and-easy-to-perform-in-senile-patients,-with-advantages-of-retaining-bladder-functions-and-sexual-functions.It-is-a-proper-alternative-for-patients-who-refuse-or-intolerant-to-radical-cystactomy-.