中国医院用药评价与分析
中國醫院用藥評價與分析
중국의원용약평개여분석
EVALUATION AND ANAL YSIS OF DRUG-USE IN HOSPITALS OF CHINA
2014年
8期
700-702
,共3页
益心舒胶囊%低分子肝素钙%慢性肺源性心脏病%急性加重期
益心舒膠囊%低分子肝素鈣%慢性肺源性心髒病%急性加重期
익심서효낭%저분자간소개%만성폐원성심장병%급성가중기
Yixinshu capsules%Low molecular weight heparin calcium injection%Chronic pulmonary heart disease%Acute ex-acerbation
目的：观察益心舒胶囊联合低分子肝素钙注射液治疗慢性肺源性心脏病（简称肺心病）急性加重期患者的疗效。方法：选取我院2012年1月至2014年2月的住院患者80例，分为两组（各40例）。对照组给予常规吸氧、平喘、化痰、扩张支气管、合理抗生素及减轻心脏负荷等综合治疗；治疗组在对照组治疗基础上加用益心舒胶囊（每次3粒，每日3次，疗程28 d）与低分子肝素钙注射液（1 ml/d，皮下注射，疗程14 d）。结果：治疗组有效率显著高于对照组（P＜0.05）。血气分析指标方面，治疗组PaO2、PaCO2的改善均明显优于对照组（P＜0.05）。血液流变学方面，与治疗前相比，治疗组治疗后的全血高切黏度、全血低切黏度、血浆黏度、红细胞比容、纤维蛋白原、血红蛋白定量和红细胞计数等指标均明显下降（P＜0.05）；与对照组治疗后比较，治疗组各项指标均明显下降（P＜0.05）。结论：益心舒胶囊联合低分子肝素钙注射液治疗慢性肺心脏病急性加重期患者安全、有效，无明显副作用。
目的：觀察益心舒膠囊聯閤低分子肝素鈣註射液治療慢性肺源性心髒病（簡稱肺心病）急性加重期患者的療效。方法：選取我院2012年1月至2014年2月的住院患者80例，分為兩組（各40例）。對照組給予常規吸氧、平喘、化痰、擴張支氣管、閤理抗生素及減輕心髒負荷等綜閤治療；治療組在對照組治療基礎上加用益心舒膠囊（每次3粒，每日3次，療程28 d）與低分子肝素鈣註射液（1 ml/d，皮下註射，療程14 d）。結果：治療組有效率顯著高于對照組（P＜0.05）。血氣分析指標方麵，治療組PaO2、PaCO2的改善均明顯優于對照組（P＜0.05）。血液流變學方麵，與治療前相比，治療組治療後的全血高切黏度、全血低切黏度、血漿黏度、紅細胞比容、纖維蛋白原、血紅蛋白定量和紅細胞計數等指標均明顯下降（P＜0.05）；與對照組治療後比較，治療組各項指標均明顯下降（P＜0.05）。結論：益心舒膠囊聯閤低分子肝素鈣註射液治療慢性肺心髒病急性加重期患者安全、有效，無明顯副作用。
목적：관찰익심서효낭연합저분자간소개주사액치료만성폐원성심장병（간칭폐심병）급성가중기환자적료효。방법：선취아원2012년1월지2014년2월적주원환자80례，분위량조（각40례）。대조조급여상규흡양、평천、화담、확장지기관、합리항생소급감경심장부하등종합치료；치료조재대조조치료기출상가용익심서효낭（매차3립，매일3차，료정28 d）여저분자간소개주사액（1 ml/d，피하주사，료정14 d）。결과：치료조유효솔현저고우대조조（P＜0.05）。혈기분석지표방면，치료조PaO2、PaCO2적개선균명현우우대조조（P＜0.05）。혈액류변학방면，여치료전상비，치료조치료후적전혈고절점도、전혈저절점도、혈장점도、홍세포비용、섬유단백원、혈홍단백정량화홍세포계수등지표균명현하강（P＜0.05）；여대조조치료후비교，치료조각항지표균명현하강（P＜0.05）。결론：익심서효낭연합저분자간소개주사액치료만성폐심장병급성가중기환자안전、유효，무명현부작용。
OBJECTIVE:To evaluate the efficacy of Yixinshu capsules plus Low molecular weight heparin calcium injection for acute exacerbation of chronic pulmonary heart disease. METHODS:Eighty patients hospitalized in our hospital between Jan. 2012 and Feb. 2014 were assigned to two groups of 40 each. The control group was routinely given comprehensive treatment includ-ing oxygen inhalation,antiasthmatic and phlegm-relieving drugs,bronchodilators,antibiotics and drugs for reducing cardiac stress, while the treatment group was given add-on Yixinshu capsules(3 capsules each time,3 times daily)for 28 days plus Low molecu-lar weight heparin calcium injection(1 ml daily)subcutaneously for 14 days. RESULTS:The effective rate in the treatment group was significantly higher than in the control group (P<0.05). Blood gas analysis showed significantly better improvement in pH, PaO2 and PaCO2 in the treatment group than in the control group(P<0.05). With regard to hemorheology,the indicators including high shear whole blood viscosity,low shear whole blood viscosity,plasma viscosity,hematocrit,fibrinogen,hemoglobin quantita-tion and red blood cell count were all significantly decreased in the treatment group after treatment as compared with before treat-ment (P<0.05);compared with the control group,indicators in the treatment group were significantly decreased after treatment (P<0.05). CONCLUSIONS:Treatment for acute exacerbation of chronic pulmonary heart disease with Yixinshu capsules plus Low molecular weight heparin calcium injection is proved to be safe and effective.
